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Animal models for induction of diabetes and its complications
ObjectivesAnimal models are widely used to develop newer drugs for treatment of diabetes and its complications. We conducted a systematic review to...
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Toxoplasma gondii infection in slaughtered domestic ruminants in Northwest Ethiopia: occurrence, bioassay and virulence assessment
This study investigated the occurrence, isolation and virulence of Toxoplasma gondii in slaughtered domestic ruminants in Gondar, Northwest Ethiopia....
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Effects on in Vitro Growth of Babesia Microti by Cells and Serum from B. Microti and Schistosoma Mansoni Infected Mice
The effect of peritoneal macrophages and serum from mice infected with Babesia microti, Schistosoma mansoni and B. microti plus S. mansoni on the...
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Anti-helminthic effect of Punica granatum peel extract on Trichinella spiralis worms and muscle larvae: in vitro and in vivo studies
Trichinella spiralis ( T. spiralis ) is a prevalent foodborne intestinal parasite in many develo** countries. Albendazole (ABZ) is the drug of choice...
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Stem Cell Treatment Trials for Regeneration of Testicular Tissue in Laboratory Animals
Infertility is a serious medical, economic, and psychological problem in the society. Male factor infertility, due to defective spermatogenesis as a...
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Towards a Large-Scale Assessment of the Relationship Between Biological and Chronological Aging: The Inspire Mouse Cohort
Aging is the major risk factor for the development of chronic diseases. After decades of research focused on extending lifespan, current efforts seek...
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Human T-cell lymphotropic virus type 1 (HTLV-1) proposed vaccines: a systematic review of preclinical and clinical studies
BackgroundNumerous vaccination research experiments have been conducted on non-primate hosts to prevent or control HTLV-1 infection. Therefore,...
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Strain Comparison in Rats Differentiates Strain-Specific from More General Correlates of Noise-Induced Hearing Loss and Tinnitus
Experiments in rodent animal models help to reveal the characteristics and underlying mechanisms of pathologies related to hearing loss such as...
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Co-administration of exercise training and melatonin on the function of diabetic heart tissue: a systematic review and meta-analysis of rodent models
PurposeDiabetes mellitus (DM), a hyperglycemic condition, occurs due to the failure of insulin secretion and resistance. This study investigated the...
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A comprehensive and critical overview of schistosomiasis vaccine candidates
A digenetic platyhelminth Schistosoma is the causative agent of schistosomiasis, one of the neglected tropical diseases that affect humans and...
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Response of outbred albino mice to concomitant Heligmosomoides bakeri, Plasmodium berghei and Trypanosoma brucei infections
To investigate the response of mice to concomitant infections with Trypanosoma brucei ( Tb ), Plasmodium berghei (Pb) and Heligmosomoides bakeri (Hb)...
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Subchondral bone remodeling patterns in larger animal models of meniscal injuries inducing knee osteoarthritis – a systematic review
PurposeElucidating subchondral bone remodeling in preclinical models of traumatic meniscus injury may address clinically relevant questions about...
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HIPEC-Induced Acute Kidney Injury: A Retrospective Clinical Study and Preclinical Model
BackgroundHyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery (CRS) is the treatment of choice for selected...
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Activity of Chymase, Tonin, and Calpains in Tissues of Male and Female Rats of Different Ages
AbstractThe activity of chymase, tonin and calpains has been studied in the blood serum and tissues of the cerebral cortex (CC), lungs, heart, liver,...
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Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic–clonic seizure model in mice
Increasing evidence indicates that some antiarrhythmic drugs play a pivotal role in seizures, not only in vivo studies on animals, but also in...
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MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity
PurposeMDMA is a psychoactive drug that has been increasingly abused worldwide, due to its entactogenic properties. However, concerns on its safety...
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Effect of Gallic acid and Myricetin on ovarian cancer models: a possible alternative antitumoral treatment
BackgroundOvarian cancer is the leading cause of mortality among malignant gynecological tumors. Surgical resection and chemotherapy with intravenous...
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Variation in faecal worm egg counts of experimentally infected goats and mice with time of day and its implications in diagnosis of helminthosis
Faecal worm egg counts (FEC) are very important indicators in assessing the intensity of helminth infections in animal hosts and inform decisions...
