Search
Search Results
-
Osteonectin bidirectionally regulates osteoblast mineralization
ObjectiveThe aim of this study was to investigate whether Osteonectin/Secreted protein acidic and rich in cysteine (ON/SPARC) had a two-way...
-
MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression
Stimulating bone formation potentially suggests therapeutics for orthopedic diseases including osteoporosis and osteoarthritis. Osteoblasts are key...
-
The extracts of osteoblast developed from adipose-derived stem cell and its role in osteogenesis
Cell-based therapy has become an achievable choice in regenerative medicines, particularly for musculoskeletal disorders. Adipose-derived stem cells...
-
Geniposide suppressed OX-LDL-induced osteoblast apoptosis by regulating the NRF2/NF-κB signaling pathway
BackgroundOsteoporosis (OP), due to microarchitectural alterations, is associated with decreased bone mass, declined strength, and increased fracture...
-
Involvement of RAMP1/p38MAPK signaling pathway in osteoblast differentiation in response to mechanical stimulation: a preliminary study
ObjectiveThe present study aimed to investigate the underlying mechanism of mechanical stimulation in regulating osteogenic differentiation.
...
-
The direct impact of pegvisomant on osteoblast functions and bone development
PurposeAcromegaly is a chronic disease characterized by growth hormone (GH) hypersecretion, usually caused by a pituitary adenoma, resulting in...
-
Bioenergetic Metabolism In Osteoblast Differentiation
Purpose of ReviewOsteoblasts are responsible for bone matrix production during bone development and homeostasis. Much is known about the...
-
RUNX2 promotes the suppression of osteoblast function and enhancement of osteoclast activity by multiple myeloma cells
RUNX2 is a transcription factor that participates in osteoblast differentiation and chondrocyte maturation and plays an important role in the...
-
Knockdown of the UL-16 binding protein 1 promotes osteoblast differentiation of human mesenchymal stem cells by activating the SMAD2/3 pathway
Osteoporosis is caused by the imbalance of osteoblasts and osteoclasts. The regulatory mechanisms of differentially expressed genes (DEGs) in...
-
Mechanism of Circ_HECW2 regulating osteoblast apoptosis in osteoporosis by attenuating the maturation of miR-1224-5p
BackgroundOsteoporosis (OP) poses a significant clinical challenge with escalating morbidity. This study explores Circ_HECW2 expression in OP...
-
Mechanical stretching determines the orientation of osteoblast migration and cell division
Osteoblasts alignment and migration are involved in the directional formation of bone matrix and bone remodeling. Many studies have demonstrated that...
-
Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration From Basic Science to Clinical Applications
This book integrates the current basic and clinical knowledge in the area of biophysical stimulation of osteoblast for in vitro and in vivo live bone...
-
Glucosamine delays the progression of osteoporosis in senile mice by promoting osteoblast autophagy
BackgroundSenile osteoporosis (SOP) is one of the most prevalent diseases that afflict the elderly population, which characterized by decreased...
-
Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing
Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease...
-
MiR-218-5p-dependent SOCS3 downregulation increases osteoblast differentiation inpostmenopausal osteoporosis
BackgroundPostmenopausal osteoporosis (POP) is a prevalent skeletal disease among elderly women. Previous study indicated that suppressor of cytokine...
-
Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice
Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene mutations lead to fragile X syndrome, cognitive disorders, and, in some individuals, scoliosis...
-
Resveratrol induces proliferation and differentiation of mouse pre-osteoblast MC3T3-E1 by promoting autophagy
BackgroundIn mouse, it was discovered that resveratrol (Res) enhanced osteoporosis (OP) by boosting osteogenesis. Besides, Res can also have an...
-
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway
BackgroundSteroid-induced avascular necrosis of the femoral head (SANFH) is characterized by osteoblast apoptosis, leading to a loss of bone...
-
Bone marrow mesenchymal stem cell-derived exosomes promote osteoblast proliferation, migration and inhibit apoptosis by regulating KLF3-AS1/miR-338-3p
AimThis study aimed to investigate the effect and mechanism of bone marrow mesenchymal stem cell-derived exosomes on osteoblast function.
...
-
Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway
BackgroundOsteoporosis is a very common skeletal disorder that increases the risk of fractures. However, the treatment of osteoporosis is...
