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Kidney fibrosis: from mechanisms to therapeutic medicines
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney fibrosis, characterized by excessive extracellular matrix...
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The mechanisms and therapeutic potential of long noncoding RNA NEAT1 in fibrosis
Fibrosis is the excess deposition of extracellular matrix involved in the pathogenesis of chronic diseases and finally leads to the disruption of...
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Ovarian fibrosis: molecular mechanisms and potential therapeutic targets
Ovarian fibrosis, characterized by the excessive proliferation of ovarian fibroblasts and the accumulation of extracellular matrix (ECM), serves as...
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ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model
BackgroundSystemic sclerosis (SSc), with unclear pathophysiology, is a paradigmatic rheumatic disease of immunity dysfunction-driven multi-organ...
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Prognostic value of the liver fibrosis marker fibrosis-5 index in patients with severe isolated tricuspid regurgitation: comparison with fibrosis-4 index
The fibrosis-4 index (FIB4), a liver fibrosis maker, has been shown to be associated with the prognosis in patients with severe isolated tricuspid...
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Mitophagy in renal interstitial fibrosis
As a high energy consumption organ, kidney relies on a large number of mitochondria to ensure normal physiological activities. Under specific...
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Hepatic inflammatory responses in liver fibrosis
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are characterized by persistent inflammation and...
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Optimized New Shengmai Powder modulation of cAMP/Rap1A signaling pathway attenuates myocardial fibrosis in heart failure
BackgroundOptimized New Shengmai Powder (ONSMP) is a traditional Chinese medicine formula with significant anti-heart failure and myocardial fibrosis...
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A Rare Case of Retroperitoneal Fibrosis Caused By IgG4-Related Disease
Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition causing tissue fibrosis, resulting in underlying organ destruction. IgG4-RD...
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Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
Sepsis, a severe systemic inflammatory response to infection, remains a leading cause of morbidity and mortality worldwide. Exosomes, as mediators of...
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Inflammation accelerating intestinal fibrosis: from mechanism to clinic
Intestinal fibrosis is a prevalent complication of IBD that that can frequently be triggered by prolonged inflammation. Fibrosis in the gut can cause...
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Short Telomere Syndrome presenting with pulmonary fibrosis, liver cirrhosis and hepatopulmonary syndrome: a case report
BackgroundIdiopathic pulmonary fibrosis is thought to result from aberrant post-injury activation of epithelial cells leading to fibroblast...
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Pathophysiology of Radiation Fibrosis Syndrome
Purpose of ReviewThe goal of this article is to provide an overview of radiation therapy followed by a description of the pathophysiology underlying...
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Citrus alkaline extracts improve LPS-induced pulmonary fibrosis via epithelial mesenchymal transition signals
BackgroundAcute respiratory distress syndrome (ARDS) is a serious life threatening clinical critical illness. ARDS-related pulmonary fibrosis is a...
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Progress in research on mesenchymal stem cells and their extracellular vesicles for treating fibrosis in systemic sclerosis
Systemic sclerosis (SSc) refers to an autoimmune disease characterized by immune dysfunction, vascular endothelial damage, and multi-organ fibrosis....
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Molecular Mechanisms Underlying Systemic Sclerosis–Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: an Update
Purpose of reviewSystemic sclerosis–associated interstitial lung disease (SSc-ILD) and idiopathic pulmonary fibrosis (IPF) are fatal fibrotic lung...
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Bone-organ axes: bidirectional crosstalk
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various...
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Noninvasive models for the prediction of liver fibrosis in patients with chronic hepatitis B
ObjectiveTo evaluate the diagnostic accuracy of aspartate aminotransferase(AST)/ alanine transaminase (ALT), AST to platelet ratio index (APRI),...
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Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronically progressive fibrotic pulmonary disease characterized by an uncertain etiology, a poor...
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Single-cell sequencing analysis fibrosis provides insights into the pathobiological cell types and cytokines of radiation-induced pulmonary fibrosis
BackgroundRadiotherapy is an essential treatment for chest cancer. Radiation-induced pulmonary fibrosis (RIPF) is an almost irreversible interstitial...
