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Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?
Purpose of ReviewAntagonists of mu-opioid receptor role in cancer progression remains to be elucidated. The objective of this review was to summarize...
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Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade
Non-human animal studies outline precise mechanisms of central mu-opioid regulation of pain, stress, affiliation and reward processing. In humans,...
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Metabolic Profiles Associated with Opioid Use and Opioid Use Disorder: a Narrative Review of the Literature
Purpose of ReviewOpioid use disorder (OUD) is a chronic, relapsing condition that is epidemic in the USA. OUD is associated with serious adverse...
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Therapeutic Innovations Against Opioid Tolerance and Addiction
Purpose of ReviewOpioids have a long history of use for relief of pain dating back thousands of years. Opium derived from the poppy plant is one of...
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Selective Opioid Antagonists Following Bowel Resection for Prevention of Postoperative Ileus: a Systematic Review and Meta-analysis
BackgroundPostoperative ileus (POI) remains a common complication following bowel resection. Selective opioid antagonists have been increasingly...
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µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice
Mood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides,...
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Cancer Pain Management in Patients with Opioid Use Disorder
Purpose of reviewUpdated cancer pain management recommendations considering the rise of opioid use disorder (OUD) and opioid overdose deaths. Few...
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Neuropsychiatric Effects Associated with Opioid-Based Management for Palliative Care Patients
Purpose of ReviewThe abundance of opioids administered in the palliative care setting that was once considered a standard of care is at present...
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Total-body imaging of mu-opioid receptors with [11C]carfentanil in non-human primates
PurposeMu-opioid receptors (MORs) are widely expressed in the central nervous system (CNS), peripheral organs, and immune system. This study measured...
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A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer
IntroductionOpioid-induced constipation (OIC) is one of the most common side effects in patients with cancer treated with opioid analgesics. The...
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AM6527, a neutral CB1 receptor antagonist, suppresses opioid taking and seeking, as well as cocaine seeking in rodents without aversive effects
Preclinical research has demonstrated the efficacy of CB1 receptor (CB1R) antagonists in reducing drug-taking behavior. However, clinical trials with...
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Pharmacological treatment of cancer pain and opioid induced nausea and vomiting: online survey and comparison with current guidelines
PurposeWe assumed that in Palliative Care, even in common clinical situations, the choice of drugs differs substantially between physicians....
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Subthreshold opioid use disorder prevention (STOP) trial: a cluster randomized clinical trial: study design and methods
BackgroundPreventing progression to moderate or severe opioid use disorder (OUD) among people who exhibit risky opioid use behavior that does not...
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The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear....
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Understanding the Causal Relationships Between Opioid Dependence and Risk of Mental Disorders: A Comprehensive Two-Sample Mendelian Randomization Study
Observational studies have reported positive associations between opioid dependence and major mental disorders. However, the causal relationships and...
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Aticaprant, a kappa opioid receptor antagonist, and the recovered ‘interest and pleasure’ in the concept of major depressive disorder
Lack of positive mood and anhedonia probably are the most specific depressive symptoms. Anhedonia is a multifaceted concept: the clinical language...
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Effect of TRV130 and methadone on fentanyl-vs.-food choice and somatic withdrawal signs in opioid-dependent and post-opioid-dependent rats
The high efficacy mu-opioid receptor (MOR) agonist methadone is an effective opioid use disorder (OUD) medication used exclusively in...
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The Role of Medicinal Cannabis as an Emerging Therapy for Opioid Use Disorder
This narrative review explores current insights into the potential use of medicinal cannabis-related products as an emerging therapy for opioid use...
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Possible unusual presentation of opioid side effect in a child: a case report
Atypical presentations are commonly encountered in the Pediatric intensive care unit (PICU) but having a high index of suspicion is crucial to...
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Robotic living donor nephrectomy is associated with reduced post-operative opioid use compared to hand-assisted laparoscopic approach
BackgroundRobotic donor nephrectomy (RDN) has emerged as a safe alternative to laparoscopic donor nephrectomy (LDN). Having previously demonstrated...
