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Oligodendrocytes matter: a review of animal studies on early adversity
Exposure to adversities in early life appears to affect the development of white matter, especially oligodendrocytes. Furthermore, altered...
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Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality
Sociality is an instinctive property of organisms that live in relation to others and is a complex characteristic of higher order brain functions....
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Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia
BackgroundStroke is a leading cause of death and disability worldwide. A major factor in brain damage following ischemia is excitotoxicity caused by...
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Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes
Early-life adversity is associated with an increased risk of psychopathology, including mood disorders, later in life. Early-life stress affects...
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Cannabinoids modulate proliferation, differentiation, and migration signaling pathways in oligodendrocytes
Cannabinoid signaling, mainly via CB1 and CB2 receptors, plays an essential role in oligodendrocyte health and functions. However, the specific...
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Reduced number of satellite oligodendrocytes of pyramidal neurons in layer 5 of the prefrontal cortex in schizophrenia
Neuroimaging, genetic and molecular biological studies have shown impaired intra-cortical myelination in patients with schizophrenia, particularly in...
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Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination
Major depressive disorder (MDD) is a chronic debilitating illness affecting yearly 300 million people worldwide. Oligodendrocyte-lineage cells have...
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Altered regulation of oligodendrocytes associated with parvalbumin neurons in the ventral hippocampus underlies fear generalization in male mice
Fear generalization is a neurobiological process by which an organism interprets a novel stimulus as threatening because of its similarity to...
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Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes
Glutamatergic neurotransmission dysfunction and the early involvement of the hippocampus have been proposed to be important aspects of the...
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Numerical density of oligodendrocytes and oligodendrocyte clusters in the anterior putamen in major psychiatric disorders
There is increasing evidence to support the notion that oligodendrocyte and myelin abnormalities may contribute to the functional dysconnectivity...
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Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS
Aging affects all cell types in the CNS and plays an important role in CNS diseases. However, the underlying molecular mechanisms driving these...
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Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of...
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Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy
Microtubule-associated protein tau ( MAPT ) aggregates in neurons, astrocytes and oligodendrocytes in a number of neurodegenerative diseases, including...
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Abnormal oligodendrocyte function in schizophrenia explains the long latent interval in some patients
A puzzling feature of schizophrenia, is the long latency between the beginning of neuropathological changes and the clinical presentation that may be...
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Tropism of Newcastle disease virus strains for chicken neurons, astrocytes, oligodendrocytes, and microglia
BackgroundNewcastle disease (ND), which is caused by infections of poultry species with virulent strains of Avian orthoavulavirus-1, also known as...
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FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury
BackgroundNeutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury (TBI)....
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Cross-regional homeostatic and reactive glial signatures in multiple sclerosis
Multiple sclerosis (MS) is a multifocal and progressive inflammatory disease of the central nervous system (CNS). However, the compartmentalized...
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Role of regulatory T cells in spinal cord injury
Spinal cord injury is an intricate process involving a series of multi-temporal and multi-component pathological events, among which inflammatory...
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The role of glial autophagy in Alzheimer’s disease
Although Alzheimer’s disease is the most pervasive neurodegenerative disorder, the mechanism underlying its development is still not precisely...
