Search
Search Results
-
Prospective benchmarking of an observational analysis in the SWEDEHEART registry against the REDUCE-AMI randomized trial
Prospective benchmarking of an observational analysis against a randomized trial increases confidence in the benchmarking process as it relies...
-
Esophageal Self-Dilation in Benign Refractory Esophageal Strictures: Outcomes from a Randomized Controlled Trial and a Prospective Observational Study
BackgroundPatients with benign esophageal strictures may not maintain a response to endoscopic dilation, stenting, incisional or injectional...
-
Long-term medication for ADHD (LMA) trial: 2-year prospective observational study in children and adolescents. Core symptoms, daily functioning, and comorbidity outcomes
More knowledge is needed about long-term ADHD medication and symptom, daily functioning, comorbidity, and tolerability outcomes. This “Long-term...
-
On the estimation of the effect of weight change on a health outcome using observational data, by utilising the target trial emulation framework
Background/ObjectivesWhen studying the effect of weight change between two time points on a health outcome using observational data, two main...
-
RAPIDIRON Trial follow-up study — the RAPIDIRON-KIDS Study: protocol of a prospective observational follow-up study
BackgroundAnemia is a worldwide problem with iron deficiency being the most common cause. When anemia occurs in pregnancy, it increases the risk of...
-
Levosimendan in patients undergoing extracorporeal membrane oxygenation after cardiac surgery: an emulated target trial using observational data
BackgroundRetrospective cohorts have suggested that levosimendan may facilitate the weaning of veno-arterial extracorporeal membrane oxygenation...
-
Whole-Body Electrostatic Pain Treatment in Adults with Chronic Pain: A Prospective Multicentric Observational Clinical Trial
IntroductionIn the treatment of patients with chronic pain, whole-body electrostatic therapy using the Elosan Cabin C1 has been proposed as an...
-
SWAT 84: effects of same-day consent vs delayed consent on the recruitment and retention of trial participants—an observational SWAT
Background and aimThe recruitment process in a randomized trial can be challenging. Poor recruitment can have a negative impact on the allocated...
-
Adherence to a lifestyle monitoring system in patients with heart disease: protocol for the care-on prospective observational trial
BackgroundLifestyle factors such as physical fitness, dietary habits, mental stress, and sleep quality, are strong predictors of the occurrence,...
-
The feasibility of team care for women seeking to plan a vaginal breech birth (OptiBreech 1): an observational implementation feasibility study in preparation for a pilot trial
BackgroundOptiBreech Care is a care pathway for breech presentation at term, including where chosen, physiological breech birth attended by...
-
Target trial emulation of carfilzomib safety among patients with relapsed/refractory multiple myeloma using a nationwide observational data in Korea
PurposeCarfilzomib, commonly used for relapsed/refractory multiple myeloma (RRMM), has been associated with various adverse events in randomized...
-
Using observational study data as an external control group for a clinical trial: an empirical comparison of methods to account for longitudinal missing data
BackgroundObservational data are increasingly being used to conduct external comparisons to clinical trials. In this study, we empirically examined...
-
Association between preoperative frailty and myocardial injury after noncardiac surgery in geriatric patients: study protocol for a prospective, multicentre, real-world observational, cohort trial
IntroductionFrailty has become a worldwide health burden that has a large influence on public health and clinical practice. The incidence of frailty...
-
ST-T segment changes in prehospital emergency physicians in the field: a prospective observational trial
AimsDue to time-critical decision-making, physical strain and the uncontrolled environment, prehospital emergency management is frequently associated...
-
Observational Learning in Surgical Skill Development
Observation plays a key role in the development of surgical skills, as it allows trainees to learn from experts and improve their performance through...
-
Use of near infrared spectroscopy for the prediction of perioperative complications in patients undergoing elective microsurgical resection of cerebral arteriovenous malformations- a prospective observational trial (NIRSCAM trial)
PurposeCerebral arteriovenous malformations (AVM) represent focal abnormal areas of low resistance circulation which render the peri-nidal neuronal...
-
Electrical Impedance Tomography as a monitoring tool during weaning from mechanical ventilation: an observational study during the spontaneous breathing trial
BackgroundProlonged weaning from mechanical ventilation is associated with poor clinical outcome. Therefore, choosing the right moment for weaning...
-
Assessing trial representativeness using serious adverse events: an observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data
BackgroundThe applicability of randomised controlled trials of pharmacological agents to older people with frailty/multimorbidity is often uncertain,...
-
Does Being In-Person Matter? Demonstrating the Feasibility and Reliability of Fully Remote Observational Data Collection
Many conventional research methods employed in randomized controlled trials were not possible during the height of the COVID-19 pandemic. In...
-
Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago
BackgroundLiterature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided...