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Causal inference and observational data
Observational studies using causal inference frameworks can provide a feasible alternative to randomized controlled trials. Advances in statistics,...
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Observational Learning in Surgical Skill Development
Observation plays a key role in the development of surgical skills, as it allows trainees to learn from experts and improve their performance through...
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Quasi-rerandomization for observational studies
BackgroundIn the causal analysis of observational studies, covariates should be carefully balanced to approximate a randomized experiment. Numerous...
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Statistical Confounding in Observational Research and Center Performance Evaluations in Organ Transplantation
Purpose of ReviewTo describe statistical confounding and the impact of observational research in transplantation. Further, to evaluate potential...
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Osteoarthritis and hypertension: observational and Mendelian randomization analyses
BackgroundThe association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and the underlying...
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Prospective benchmarking of an observational analysis in the SWEDEHEART registry against the REDUCE-AMI randomized trial
Prospective benchmarking of an observational analysis against a randomized trial increases confidence in the benchmarking process as it relies...
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Clinical and economic impacts of a modified-observational screening approach to well-appearing infants born to mothers with chorioamnionitis
ObjectiveTerm infants born to mothers with chorioamnionitis are at risk for early-onset sepsis (EOS). We aimed to measure the impact of changing from...
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Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials
Recent high-profile failures of Alzheimer disease treatments at the clinical trial stage have led to renewed efforts to identify and test novel...
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Study Design: Observational Studies
Observational study designs are those where the investigator/researcher just observes and does not carry out any intervention(s)/actions to alter the...
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Antibiotics vs observational therapy in acute uncomplicated diverticulitis, a systemic review and meta-analysis
PurposeAntibiotics have long been recommended as a form of conservative therapy in patients with acute uncomplicated diverticulitis despite no...
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Time to Stop the Witch-Hunt Against Observational Studies
Surgical research has been often criticized for its over-dependence on observational studies (OSs) instead of stronger evidence of more...
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A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases
Treatment effects are often anticipated to vary across groups of patients with different baseline risk. The Predictive Approaches to Treatment Effect...
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Cement augmentation for proximal humerus fractures: a meta-analysis of randomized trials and observational studies
IntroductionIt is unclear if elderly patients treated with plate osteosynthesis for proximal humerus fractures benefit from cement augmentation. This...
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Esophageal Self-Dilation in Benign Refractory Esophageal Strictures: Outcomes from a Randomized Controlled Trial and a Prospective Observational Study
BackgroundPatients with benign esophageal strictures may not maintain a response to endoscopic dilation, stenting, incisional or injectional...
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Revascularization with BYCROSS atherectomy device- protocol of a prospective multicenter observational study
BackgroundThe BYCROSS™ device is a novel device intended for use in atherectomy of the peripheral arterial disease (PAD). With the BYCROSS™...
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Development of Medical Imaging Data Standardization for Imaging-Based Observational Research: OMOP Common Data Model Extension
The rapid growth of artificial intelligence (AI) and deep learning techniques require access to large inter-institutional cohorts of data to enable...
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Association between alcohol consumption and sleep traits: observational and mendelian randomization studies in the UK biobank
Previous studies have shown that excessive alcohol consumption is associated with poor sleep. However, the health risks of light-to-moderate alcohol...
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Prevalence of portal vein thrombosis in non-alcoholic fatty liver disease: a meta-analysis of observational studies
Portal vein thrombosis (PVT) is a common complication of cirrhosis as a result of portal hypertension and modification in the hemostatic balance....
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An exploration into the causal relationships between educational attainment, intelligence, and wellbeing: an observational and two-sample Mendelian randomisation study
Educational attainment is associated with a range of positive outcomes, yet its impact on wellbeing is unclear, and complicated by high correlations...
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A Prospective Observational Study of Posterior Tibial Nerve Stimulation in Multiple Sclerosis
Introduction and HypothesisThe objective was to examine the outcomes of posterior tibial nerve stimulation (PTNS) on bladder, bowel, and sexual...
