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Sublingual Dexmedetomidine for Agitation Associated with Schizophrenia or Bipolar Disorder: A Post Hoc Analysis of Number Needed to Treat, Number Needed to Harm, and Likelihood to be Helped or Harmed
IntroductionThe objective was to use the evidence-based medicine metrics of number needed to treat, number needed to harm, and likelihood to be...
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Benefits and Risks of Antihyperlipidemic Medication in Adults with Different Low-Density Lipoprotein Cholesterol Based on the Number Needed to Treat
PurposeThe objective of this investigation is to examine the benefits and potential risks of these drugs in individuals by varying baseline...
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Comparative profiles of lubiprostone, linaclotide, and elobixibat for chronic constipation: a systematic literature review with meta-analysis and number needed to treat/harm
ObjectiveTo comprehensively evaluate the efficacy, safety, patient symptoms, and quality-of-life (QoL) of lubiprostone, linaclotide, and elobixibat...
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Reduction in number to treat versus number needed to treat
BackgroundWe propose a new measure of treatment effect based on the expected reduction in the number of patients to treat (RNT) which is defined as...
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Number Needed to Treat Network Meta-Analysis to Compare Biologic Drugs for Moderate-to-Severe Psoriasis
IntroductionNumber needed to treat (NNT) estimates are a practical metric to help identify the most effective therapies. Our objective is to compare...
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Cost per Patient Achieving Treatment Targets and Number Needed to Treat with Tirzepatide Versus Semaglutide 1 mg in Patients with Type 2 Diabetes in the United States
IntroductionAchieving glycemic control can help reduce complications of type 2 diabetes (T2D). This study compared the pharmacy cost per responder...
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Benefit–Risk Assessment of Galcanezumab Versus Placebo for the Treatment of Episodic and Chronic Migraine Using the Metrics of Number Needed to Treat and Number Needed to Harm
IntroductionSubcutaneous galcanezumab was an effective, well-tolerated preventive treatment for adults with episodic (EM) or chronic migraine (CM) in...
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Pharmacoeconomic analysis of biologics and methotrexate for rheumatoid arthritis from the standpoint of the number needed to treat concept under the Japanese health insurance system
ObjectivesTo evaluate the cost-effectiveness of biologics and methotrexate (MTX) for rheumatoid arthritis (RA) using the number needed to treat (NNT)...
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Nivolumab versus placebo as adjuvant therapy for resected stage III melanoma: a propensity weighted indirect treatment comparison and number needed to treat analysis for recurrence-free survival and overall survival
BackgroundRecurrence-free survival (RFS) and overall survival (OS) data for adjuvant nivolumab versus placebo (proxy for routine surveillance) in...
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Characteristics of subsequent contralateral proximal femoral fracture: more convenient access is needed to treat osteoporosis
BackgroundPatients with proximal femoral fracture (PFF) have high mortality and many complications. Osteoporosis increases the risk of subsequent...
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Treat-to-Target in Atopic Dermatitis
Atopic dermatitis is one of the most common inflammatory skin diseases among children and adults. Over the last 5 years, the armamentarium for the...
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Accelerometer-derived sleep metrics in mild and difficult-to-treat asthma
IntroductionPoor sleep health is associated with increased asthma morbidity and mortality. Accelerometers have been validated to assess sleep...
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Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine
Bipolar disorder’s core feature is the pathological disturbances in mood, often accompanied by disrupted thinking and behavior. Its complex and...
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Aflibercept to treat retinopathy of prematurity: need for more research
Until recently, the standard care for retinopathy of prematurity (ROP) was destructive treatment of the peripheral avascular retina, most often using...
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Difficult-to-treat HIV in Sweden: a cross-sectional study
BackgroundOur aim was to examine the prevalence and characteristics of difficult-to-treat HIV in the current Swedish HIV cohort and to compare...
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Management of Sarcoidosis: When to Treat, How to Treat and for How Long?
Purpose of ReviewThis review draws together recent publications, consensus statements on sarcoidosis and our 25-year collective experience in...
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Treat Obesity to Treat Type 2 Diabetes Mellitus
Obesity, a multifactorial, relapsing chronic disease, serves as a gateway to a spectrum of metabolic, cardiovascular, mechanical and mental health...