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Neuropathological findings in Down syndrome, Alzheimer’s disease and control patients with and without SARS-COV-2: preliminary findings
The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many patients, with an increased...
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SARS-CoV-2 seroprevalence in patients with autoimmune rheumatic diseases versus family controls: a multi-city cross-sectional survey
There is uncertainty regarding the effect of the SARS-CoV-2 infection on patients with autoimmune rheumatic diseases (AIRD) who are on...
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In silico formulation of a next-generation multiepitope vaccine for use as a prophylactic candidate against Crimean-Congo hemorrhagic fever
BackgroundCrimean-Congo hemorrhagic fever (CCHF) is a widespread disease transmitted to humans and livestock animals through the bite of infected...
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Development and validation of a respiratory syncytial virus multiplex immunoassay
PurposeRespiratory syncytial virus (RSV) is one of the leading causes of severe respiratory disease in infants and adults. While vaccines and...
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Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy
Influenza-associated encephalopathy (IAE) is extremely acute in onset, with high lethality and morbidity within a few days, while the direct...
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Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus
Respiratory syncytial virus (RSV) is a nonsegmented, negative strand RNA virus that has caused severe lower respiratory tract infections of high...
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LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway
BackgroundOsteosarcoma is highly malignant. The migration, invasion, and chemoresistance contribute to poor prognosis of osteosarcoma. Research...
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Cycle threshold values of SARS-CoV-2 RNA in conjunctival swabs and nasopharyngeal secretions: a comparative study from a tertiary care center in India
PurposeTo detect the viral RNA load of SARS-CoV-2 in conjunctival swabs of COVID-19 patients, and compare with nasopharyngeal swabs.
Methods ...
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Clinical relevance of SARS-CoV-2 infection in late pregnancy
BackgroundEvidence on the outcome of SARS-CoV-2 infection in pregnancy is generally reassuring but yet not definitive.
MethodsTo specifically assess...
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Evaluation of eight lateral flow tests for the detection of anti-SARS-CoV-2 antibodies in a vaccinated population
BackgroundRapid determination of an individual’s antibody status can be beneficial in understanding an individual’s immune response to SARS-CoV-2 and...
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Clinical application of PARP inhibitors in ovarian cancer: from molecular mechanisms to the current status
As a kind of gynecological tumor, ovarian cancer is not as common as cervical cancer and breast cancer, but its malignant degree is higher. Despite...
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First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies
The presence of pneumoviruses in pigs is poorly documented. In this study, we used the published sequence of the nucleoprotein (N) of the recently...
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Brainstem neuropathology in two cases of COVID-19: SARS-CoV-2 trafficking between brain and lung
IntroductionSARS-CoV-2 might spread through the nervous system, reaching respiratory centers in the brainstem. Because we recently reported...
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Maternal COVID-19 causing intrauterine foetal demise with microthrombotic placental insufficiency: a case report
BackgroundPregnant women have an increased risk of getting infected with SARS-CoV-2 and are more prone to severe illness. Data on foetal demise in...
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Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis
BackgroundInfluenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease...
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Pediatric cancer patients vaccinated against SARS-CoV-2—a clinical and laboratory follow-up
BackgroundVaccination against SARS-CoV-2 is recommended for cancer patients. However, long-term data on the effectiveness in the pediatric setting...
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DNA double-strand break genetic variants in patients with premature ovarian insufficiency
Premature ovarian insufficiency (POI) is a clinically heterogeneous disease that may seriously affect the physical and mental health of women of...
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Molecular detection of bornavirus in parrots imported to China in 2022
BackgroundAvian bornavirus (ABV) is a neurotropic virus, it has been established as the primary causative agent of proventricular dilatation disease...
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Seroprevalence of human coronaviruses among patients visiting hospital-based sentinel sites in Uganda
BackgroundHuman coronaviruses are causative agents of respiratory infections with several subtypes being prevalent worldwide. They cause respiratory...
