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Therapeutic targeting of TNIK in papillary thyroid carcinoma: a novel approach for tumor growth suppression
Papillary thyroid carcinoma (PTC) is a common endocrine malignancy. The pathology of PTC is far from clear. As a kinase that can be targeted, the...
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Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach
Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In our study, we explored the...
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CRISPR–Cas9 potential for identifying novel therapeutic targets in muscle-invasive bladder cancer
Gene editing technologies help identify the genetic perturbations driving tumour initiation, growth, metastasis and resistance to therapeutics. This...
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ADAMTS7: a Novel Therapeutic Target in Atherosclerosis
Purpose of ReviewGenome-wide association studies have repeatedly linked the metalloproteinase ADAMTS7 to coronary artery disease. Here we aim to...
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Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton’s jelly-derived mesenchymal stem cells: a novel therapeutic approach
BackgroundType 2 diabetes mellitus (T2DM), characterized by β-cell dysfunction and insulin resistance (IR), presents considerable treatment...
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A Novel Comprehensive Therapeutic Approach to the Challenges of Chronic Wounds: A Brief Review and Clinical Experience Report
Following the clinical perspective and concept that a healthy body will not develop chronic wounds, the central approach for the treatment described...
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Dual Endothelin Antagonism with Aprocitentan as a Novel Therapeutic Approach for Resistant Hypertension
Purpose of ReviewResistant hypertension (RH) defined as uncontrolled blood pressure despite the use of a combination of a renin-angiotensin system...
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Therapeutic targeting approach on epithelial-mesenchymal plasticity to combat cancer metastasis
Epithelial-mesenchymal plasticity (EMP) is a process in which epithelial cells lose their characteristics and acquire mesenchymal properties, leading...
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Claudin 18.2 as a novel therapeutic target
Claudin 18.2, a tight-junction molecule predominantly found in the nonmalignant gastric epithelium, becomes accessible on the tumour cell surface...
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Malignant pleural effusion: current understanding and therapeutic approach
Malignant pleural effusion (MPE) is a common complication of thoracic and extrathoracic malignancies and is associated with high mortality and...
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Cholangiocarcinoma — novel biological insights and therapeutic strategies
In the past 5 years, important advances have been made in the scientific understanding and clinical management of cholangiocarcinoma (CCA). The...
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Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma
Activating RAS mutations are found in a subset of fusion-negative rhabdomyosarcoma (RMS), and therapeutic strategies to directly target RAS in these...
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Novel therapeutic perspectives in Noonan syndrome and RASopathies
Noonan syndrome belongs to the family of RASopathies, a group of multiple congenital anomaly disorders caused by pathogenic variants in genes...
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Short review: novel concepts in the approach to patients with amiodarone-induced thyrotoxicosis
IntroductionAmiodarone-induced thyrotoxicosis is associated with high morbidity and mortality rates. The approach to this condition is widely...
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A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models
BackgroundMantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma subtype which remains incurable despite multimodal approach including...
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Therapeutic drug monitoring in inflammatory bowel disease: A practical approach
The global burden of inflammatory bowel diseases (IBD) is estimated at 4.9 million and the global prevalence exceeds 0.3%. Multiple newer therapeutic...
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From clinical management to personalized medicine: novel therapeutic approaches for ovarian clear cell cancer
Ovarian clear-cell cancer is a rare subtype of epithelial ovarian cancer with unique clinical and biological features. Despite optimal cytoreductive...
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Novel biomolecules in targeted cancer therapy: a new approach towards precision medicine
Cancer is a major threat to human life around the globe, and the discovery of novel biomolecules continue to be an urgent therapeutic need that is...
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Osteopontin: A Novel Therapeutic Target for Respiratory Diseases
Osteopontin (OPN) is a multifunctional phosphorylated protein that is involved in physiological and pathological events. Emerging evidence suggests...
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Identification of hub genes and therapeutic siRNAs to develop novel adjunctive therapy for Duchenne muscular dystrophy
ObjectiveDuchenne muscular dystrophy (DMD) is a devastating X-linked neuromuscular disorder caused by various defects in the dystrophin gene and...
