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The Impact of OnabotulinumtoxinA vs. Placebo on Efficacy Outcomes in Headache Day Responder and Nonresponder Patients with Chronic Migraine
IntroductionThe phase 3 PREEMPT trials demonstrated efficacy and tolerability of onabotulinumtoxinA for headache prevention in adults with chronic...
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Clinical significance of the maximum standardized uptake value on positron emission tomography to predict treatment response and outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
PurposesThe association between the reduction rate of the maximum standardized uptake value (SUVmax) on positron emission tomography (PET) during...
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Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes
PurposeTo evaluate the response to nifedipine administration measured by changes in hepatic arterial (HA) flow on post-operative Doppler ultrasound...
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Efficacy of Guselkumab on Axial-Related Symptoms Through up to 2 Years in Adults with Active Psoriatic Arthritis in the Phase 3, Randomized, Placebo-Controlled DISCOVER-2 Study
IntroductionGuselkumab previously showed greater improvements versus placebo in axial symptoms in patients with psoriatic arthritis (PsA) (assessed...
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Perampanel as an Add-On Therapy in Patients with Refractory Status Epilepticus and Postanoxic Encephalopathy: A Real-Life Single-Center Retrospective Cohort Study
BackgroundData on the efficacy of perampanel in refractory status epilepticus (RSE) and postanoxic encephalopathy (PAE) are limited; its use in such...
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Symptom improvement with mirabegron treatment is associated with urobiome changes in adult women
Introduction and hypothesisMirabegron, a beta-3 agonist, is prescribed for urgency urinary incontinence (UUI). We assessed the correlation of symptom...
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The contribution of the 1H-MRS lipid signal to cervical cancer prognosis: a preliminary study
BackgroundThe aim of this study was to investigate the role of the lipid peak derived from 1 H magnetic resonance (MR) spectroscopy in assessing...
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High flow nasal cannula therapy for obstructive sleep apnea in adults
PurposeObstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by the aggravation of upper airway constriction or obstruction, and it is...
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Long-term effectiveness and safety of ustekinumab in bio-naïve and bio-experienced anti-tumor necrosis factor patients with Crohn’s disease: a real-world multicenter Brazilian study
BackgroundThe effectiveness of ustekinumab (UST) in the treatment of Crohn’s disease (CD) has been demonstrated in the pivotal Phase 3 UNITI 1 and 2...
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Infantile hemangiomas β3-adrenoceptor overexpression is associated with nonresponse to propranolol
BackgroundPropranolol (antagonist of β 1 -/β 2 -AR but minimally active against β 3 -AR) is currently the first-line treatment for infantile hemangiomas...
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Optimal Time-to-Surgery Recommendations Based on Primary Tumor Volume Regression for Patients with Resectable Esophageal Cancer after Neoadjuvant Chemoradiotherapy: A Retrospective Study
BackgroundNeoadjuvant chemoradiotherapy (NCRT) has shown promise in improving the prognosis of individuals with locally advanced esophageal squamous...
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Efficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 100-Week Results from the Phase 3 KEEPsAKE 1 Randomized Clinical Trial
IntroductionPatients with psoriatic arthritis (PsA) require treatment providing durable long-term efficacy in different disease domains as well as...
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Enthesitis and Dactylitis Resolution with Risankizumab for Active Psoriatic Arthritis: Integrated Analysis of the Randomized KEEPsAKE 1 and 2 Trials
IntroductionThe presence (vs absence) of enthesitis/dactylitis is associated with greater psoriatic arthritis (PsA) activity and reduced...
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The Proton Pump Inhibitor Nonresponder: a Behavioral Approach to Improvement and Wellness
Purpose of ReviewGastroesophageal reflux disease (GERD) is a difficult to treat medical condition, where nearly 40% of patients are refractory to...
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Predicting Abrocitinib Efficacy at Week 12 Based on Clinical Response at Week 4: A Post Hoc Analysis of Four Randomized Studies in Moderate-to-Severe Atopic Dermatitis
IntroductionEarly prediction of abrocitinib efficacy in atopic dermatitis (AD) could help identify candidates for an early dose increase. A...
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Consistent Efficacy of Apremilast in Patients with Psoriasis Regardless of Baseline Disease Severity or Special Area Involvement: Subgroup Analysis from PROMINENT
IntroductionPsoriasis involvement in special areas (e.g., scalp or nails) is associated with a great disease burden yet it is often inadequately...
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Safety and Efficacy of Upadacitinib for Atopic Dermatitis in Japan: Analysis of the 3-Year Phase 3 Rising Up Study
IntroductionUpadacitinib is an oral Janus kinase inhibitor approved in multiple countries for moderate-to-severe atopic dermatitis (AD). Here we...
