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Colchicine ameliorates myocardial injury induced by coronary microembolization through suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway
BackgroundCoronary microembolization(CME)is a common complication in acute coronary syndrome and percutaneous coronary intervention, which is closely...
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STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling
Clostridium perfringens ( C. perfringens ) infection is recognized as one of the most challenging issues threatening food safety and perplexing...
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RAGE/SNAIL1 signaling drives epithelial-mesenchymal plasticity in metastatic triple-negative breast cancer
Epithelial/Mesenchymal (E/M) plasticity plays a fundamental role both in embryogenesis and during tumorigenesis. The receptor for advanced glycation...
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Signaling pathways of chronic kidney diseases, implications for therapeutics
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized by nephron loss, inflammation, myofibroblasts activation,...
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Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) is a common condition associated with critically ill patients, characterized by bilateral chest...
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Possible therapeutic targets for NLRP3 inflammasome-induced breast cancer
Inflammation plays a major role in the development and progression of breast cancer(BC). Proliferation, invasion, angiogenesis, and metastasis are...
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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and...
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Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions
Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research,...
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Cooperation of immune regulators Tollip and surfactant protein A inhibits influenza A virus infection in mice
BackgroundInfluenza A virus (IAV) infection is a significant risk factor for respiratory diseases, but the host defense mechanisms against IAV remain...
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A comprehensive analysis of type 1 interferon gene signatures in systematic lupus erythematosus and prediction of the crucial susceptible factor for Sjögren syndrome
This study aimed to determine the role of IFN-1 gene signatures in SLE and their association with Sjögren syndrome (SS). Publicly available data from...
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Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes...
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Signaling pathways and targeted therapy for myocardial infarction
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a worldwide disease with high morbidity and high...
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cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3
Cellular inhibitor of apoptosis-1 (cIAP1) is a signaling regulator with oncogenic properties. It is involved in the regulation of signaling pathways...
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A Review of RRx-001: A Late-Stage Multi-Indication Inhibitor of NLRP3 Activation and Chronic Inflammation
Chronic unresolving inflammation is emerging as a key underlying pathological feature of many if not most diseases ranging from autoimmune conditions...
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TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling...
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Pattern recognition receptors in health and diseases
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of...
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Characterization of a small molecule modulator of inflammatory cytokine production
In the present study, the effect(s) of the immunomodulatory drug GLS-1027 on various cell types involved in inflammation were investigated. GLS-1027...
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Stimulator of interferon genes/Interferon regulatory factor 3 (STING-IRF3) and inflammasome-activation mediated pyroptosis biomarkers: a network of integrated pathways in diabetic nephropathy
BackgroundDiabetic Nephropathy (DN) is serious diabetic complication affecting the structure and function of the kidney. This study assessed the...
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Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is...
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Increased Fungal Infection Mortality Induced by Concurrent Viral Cellular Manipulations
Certain respiratory fungal pathogen mono-infections can cause high mortality rates. Several viral pathogen mono-infections, including influenza...
