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  1. New regulatory thinking is needed for AI-based personalised drug and cell therapies in precision oncology

    Until recently the application of artificial intelligence (AI) in precision oncology was confined to activities in drug development and had limited...

    Bouchra Derraz, Gabriele Breda, ... Stephen Gilbert in npj Precision Oncology
    Article Open access 30 January 2024

  2. Novel Blood-Based Biomarkers and Disease Modifying Therapies for Alzheimer’s Disease. Are We Ready for the New Era?

    Recent positive trials for novel disease modifying therapies of anti-amyloid monoclonal antibodies represent a paradigm shift in the prevention and...

    Roxanna Korologou-Linden, J. Kalsi, ... L. T. Middleton in The Journal of Prevention of Alzheimer's Disease
    Article Open access 21 May 2024

  3. New therapies for spinal muscular atrophy: where we stand and what is next

    The natural history of spinal muscular atrophy has been radically changed by the advent of improved standards of care and the availability of...

    Laura Antonaci, Maria Carmela Pera, Eugenio Mercuri in European Journal of Pediatrics
    Article Open access 17 April 2023

  4. Treating Biliary Tract Cancers: New Targets and Therapies

    Biliary tract cancers (BTCs) are rare and aggressive tumors that typically present at an advanced stage when surgical resection is no longer...

    Joseph Ho, Constance Fiocco, Kristen Spencer in Drugs
    Article 28 November 2022

  5. Sickle cell disease: combination new therapies vs. CRISPR-Cas9 potential and challenges — review article

    In 2022, sickle cell disease (SCD) continues to affect the lives of millions of people, being one of the most frequently inherited blood disorders...

    Ilham Youssry, Nardeen Ayad in Annals of Hematology
    Article 23 October 2023

  6. New and emerging therapies for diabetic kidney disease

    Ricardo Correa-Rotter, Louise J. Maple-Brown, ... Ifeoma I. Ulasi in Nature Reviews Nephrology
    Article 02 January 2024

  7. Glycaemic Control and Weight Reduction: A Narrative Review of New Therapies for Type 2 Diabetes

    Early and intensive treatment of type 2 diabetes (T2D) has been associated with lower risk of diabetes-related complications. Control of overweight...

    Luis Alberto Vázquez, Irene Romera, ... Javier Escalada in Diabetes Therapy
    Article Open access 15 September 2023

  8. Analysis of cost-effectiveness of chemotherapeutic agents and new therapies for the management of unresectable and metastatic melanoma

    Background

    The advent of targeted therapies and immunotherapies has revolutionized metastatic melanoma (MM) management but their use is associated...

    Clément Charpentier, Valéry-Pierre Riche, ... Brigitte Dreno in European Journal of Dermatology
    Article 01 March 2023

  9. Advances in neonatal cell therapies: Proceedings of the First Neonatal Cell Therapies Symposium (2022)

    Abstract

    Despite considerable advances, there is a need to improve the outcomes of newborn infants, especially related to prematurity, encephalopathy...

    Atul Malhotra, Bernard Thebaud, ... Courtney A. McDonald in Pediatric Research
    Article Open access 28 June 2023

  10. Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies

    Psoriasis is a chronic immune-mediated disorder that commonly affects adults and children. In recent years, pediatric psoriasis has increased in...

    Erina Lie, Mira Choi, ... Lawrence F. Eichenfield in Pediatric Drugs
    Article Open access 17 October 2023

  11. New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development

    The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the modulation of neuronal excitability, and a disruption of...

    Emilio Perucca, H. Steve White, Meir Bialer in CNS Drugs
    Article Open access 21 August 2023

  12. Novel therapies for growth disorders

    As we continue to understand more about the complex mechanism of growth, a plethora of novel therapies have recently been developed that aim to...

    Despoina M. Galetaki, Nadia Merchant, Andrew Dauber in European Journal of Pediatrics
    Article 13 October 2023

  13. New Topical Therapies in Development for Atopic Dermatitis

    Atopic dermatitis (AD) is a common chronic pruritic inflammatory cutaneous disease. AD is characterized by intense pruritus and enormous clinical...

    Egídio Freitas, Melinda Gooderham, Tiago Torres in Drugs
    Article 21 May 2022

  14. Monotherapy with infusion therapies – useful or not?

    Infusion pump-based therapies are an effective treatment option for patients with advanced Parkinson´s disease. Achieving monotherapy with...

    Petra Bago Rožanković, Anders Johansson, ... Per Odin in Journal of Neural Transmission
    Article 05 July 2024

  15. New Molecular Insights, and the Role of Systemic Therapies and Collaboration for Treatment of Epithelioid Hemangioendothelioma (EHE)

    Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated vascular sarcoma. EHE can have different clinical presentations from indolent...

    Silvia Stacchiotti, William Tap, ... Giacomo G Baldi in Current Treatment Options in Oncology
    Article 14 April 2023

  16. Managing the Risk of Infection in Chronic Lymphocytic Leukemia in the Era of New Therapies

    Purpose of Review

    Patients diagnosed with CLL have an increased susceptibility to infections. Over the years, there has been a shift of the treatment...

    Daniel Rivera, Alessandra Ferrajoli in Current Oncology Reports
    Article 02 April 2022

  18. Alzheimer’s Disease: Combination Therapies and Clinical Trials for Combination Therapy Development

    Alzheimer’s disease (AD) is a complex multifaceted disease. Recently approved anti-amyloid monoclonal antibodies slow disease progression by...

    Jeffrey L. Cummings, Amanda M. Leisgang Osse, ... **gchun Chen in CNS Drugs
    Article Open access 27 June 2024

  19. Astrocytes in human central nervous system diseases: a frontier for new therapies

    Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS)....

    Alexei Verkhratsky, Arthur Butt, ... Michael V. Sofroniew in Signal Transduction and Targeted Therapy
    Article Open access 13 October 2023

  20. Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?

    Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation therapies targeting...

    Sophie Béliard, Florian Mourre, René Valéro in Diabetologia
    Article Open access 20 February 2024
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