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MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway
BackgroundNeutrophilic airway inflammation is a challenge in asthma management and is associated with poor patient prognosis. Mucin 1 (MUC1), which...
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The amount of hyaluronic acid and airway remodelling increase with the severity of inflammation in neutrophilic equine asthma
BackgroundEquine asthma (EA) is a chronic lower airway inflammation that leads to structural and functional changes. Hyaluronic acid (HA) has crucial...
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miR-146a-3p as a potential novel therapeutic by targeting MBD2 to mediate Th17 differentiation in Th17 predominant neutrophilic severe asthma
Th17 (T-helper 17) cells subtype of non-T2 (non-type 2) asthma is related to neutrophilic infiltration and resistance to inhaled corticosteroids...
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A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype
BackgroundAsthma is a heterogeneous disease; therefore, biomarkers that can assist in the identification of subtypes and direct therapy are highly...
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Acute neutrophilic vasculitis (leukocytoclasia) in 36 COVID-19 autopsy brains
BackgroundHypercytokinemia, the renin-angiotensin system, hypoxia, immune dysregulation, and vasculopathy with evidence of immune-related damage are...
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Association between particulate matter containing EPFRs and neutrophilic asthma through AhR and Th17
BackgroundEpidemiological data associate high levels of combustion-derived particulate matter (PM) with deleterious respiratory outcomes, but the...
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Different expression levels of interleukin-36 in asthma phenotypes
Interleukin (IL)-36 family is closely associated with inflammation and consists of IL-36α, IL-36β, IL-36γ, and IL-36Ra. The role of IL-36 in the...
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Assessment of asthma mimics among newly diagnosed bronchial asthma patients in Zagazig University Hospitals
BackgroundBronchial asthma may mimic different diseases regarding their similar clinical presentations, so accurate assessment is required to exclude...
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Characterization and inhibition of inflammasome responses in severe and non-severe asthma
BackgroundIncreased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased...
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Relationship between Th17-mediated immunity and airway inflammation in childhood neutrophilic asthma
BackgroundThe pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to...
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Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
BackgroundPatients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme...
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Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma
BackgroundExtracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data...
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Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma
BackgroundSevere asthma is associated with substantial mortality and has unmet therapeutic need. A subset of severe asthma is characterized by...
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CFTR heterozygosity in severe asthma with recurrent airway infections: a retrospective review
RationalePatients with asthma who have neutrophilic bronchitis may have an underlying cause leading to increased susceptibility to airway infections.
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Barriers to clinical remission in severe asthma
Severe asthma is associated with an increased risk for exacerbations, reduced lung function, fixed airflow obstruction, and substantial morbidity and...
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The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma
Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant,...
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Childhood asthma phenotypes and endotypes: a glance into the mosaic
BackgroundAsthma is an inflammatory lung disease that constitutes the most common noncommunicable chronic disease in childhood. Childhood asthma...
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Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma
BackgroundThe pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and...
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Air Pollution and Diet: Potential Interacting Exposures in Asthma
Purpose of ReviewTo provide a review of emerging literature describing the impact of diet on the respiratory response to air pollution in asthma.
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Recent miRNA Research in Asthma
Purpose of ReviewThe study of microRNA in asthma has revealed a vibrant new level of gene regulation underlying asthma pathology. Several miRNAs have...
