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Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability
Reaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks, has been proposed as an endophenotype for many...
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Cognitive impairment and factors influencing depression in adolescents with suicidal and self-injury behaviors: a cross-sectional study
BackgroundNon-suicidal self-injury (NSSI) and suicide attempts (SAs) by adolescent patients with depression have become serious public health...
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Comparison of cognitive performance in first-episode drug-naïve schizophrenia, bipolar II disorder, and major depressive disorder patients after treatment
BackgroundCognitive impairment is a recognized fundamental deficit in individuals diagnosed with schizophrenia (SZ), bipolar II disorder (BD II), and...
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Risk of traumatic brain injury among patients with ADHD and their unaffected siblings
BackgroundAs the relationship between attention deficit hyperactivity disorder (ADHD) and traumatic brain injury (TBI) is gaining increasing...
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Attention as neurocognitive endophenotype of ADHD across the life span: a family study
Endophenotypes mediate pathways between genetic variations and the psychiatric phenotype, or share genetic risk with the psychiatric phenotype....
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Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample
Endophenotypes are heritable and quantifiable traits indexing genetic liability for a disorder. Here, we examined three potential endophenotypes,...
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Evaluating endophenotypes for bipolar disorder
BackgroundPhenotypic heterogeneity is a major impediment to the elucidation of the neurobiology and genetics of bipolar disorder. Endophenotype could...
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Neuropsychological, clinical and environmental predictors of severe mental disorders in offspring of patients with schizophrenia
Offspring of individuals with schizophrenia (SZCOff) are at an increased risk for this disorder. Neuropsychological decline is a core feature of the...
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Orthorexia nervosa and executive dysfunction: symptomatology is related to difficulties with behavioral regulation
PurposeThis research explored whether orthorexia nervosa is associated with deficits in executive function.
MethodsA non-clinical sample of...
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Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders
Excitation/inhibition (E/I) balance plays important roles in mental disorders. Bioactive phospholipids like lysophosphatidic acid (LPA) are...
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Artificial Intelligence on FDG PET Images Identifies Mild Cognitive Impairment Patients with Neurodegenerative Disease
The purpose of this project is to develop and validate a Deep Learning (DL) FDG PET imaging algorithm able to identify patients with any...
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Shared genetic liability for alcohol consumption, alcohol problems, and suicide attempt: Evaluating the role of impulsivity
Heavy drinking and diagnosis with alcohol use disorder (AUD) are consistently associated with risk for suicide attempt (SA). Though the shared...
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Identification of plasma metabolites associated with modifiable risk factors and endophenotypes reflecting Alzheimer’s disease pathology
Modifiable factors can influence the risk for Alzheimer’s disease (AD) and serve as targets for intervention; however, the biological mechanisms...
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Patients with first-episode psychosis in northern Taiwan: neurocognitive performance and niacin response profile in comparison with schizophrenia patients of different familial loadings and relationship with clinical features
BackgroundExamining patients with first-episode psychosis (FEP) provides opportunities to better understand the mechanism underlying these illnesses....
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Executive functions and insight in OCD: a comparative study
BackgroundAround 25 to 30% of patients with obsessive-compulsive disorder (OCD) do not respond to treatment. These patients have the longest duration...
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Neurophysiology in psychosis: The quest for disease biomarkers
Psychotic disorders affect 3% of the population at some stage in life, are a leading cause of disability, and impose a great economic burden on...
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Resting-state functional connectivity correlates of brain structural aging in schizophrenia
A large body of research has shown that schizophrenia patients demonstrate increased brain structural aging. Although this process may be coupled...
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Genotype-by-diagnosis interaction influences self-control in human cocaine addiction
Not everyone who uses drugs loses control over their intake, which is a hallmark of addiction. Although familial risk studies suggest significant...
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Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder
BackgroundThe neural correlate of cognitive deficits in bipolar disorder (BD) is an issue that warrants further investigation. However, relatively...
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Immediate visual reproduction negatively correlates with brain entropy of parahippocampal gyrus and inferior occipital gyrus in bipolar II disorder adolescents
BackgroundBrain entropy reveals complexity and irregularity of brain, and it has been proven to reflect brain complexity alteration in disease...
