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Gastric neuroendocrine neoplasms
Gastric neuroendocrine neoplasms (gNENs) display peculiar site-specific features among all NENs. Their incidence and prevalence have been rising in...
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Ontogeny of the Dyad: the Relationship Between Maternal and Offspring Neuroendocrine Function
Purpose of ReviewWe review ontogeny of the maternal-offspring neuroendocrine relationship in human pregnancy. We present bidirectional genetic,...
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Molecular and functional map** of the neuroendocrine hypothalamus: a new era begins
BackgroundRecent advances in neuroscience tools for single-cell molecular profiling of brain neurons have revealed an enormous spectrum of neuronal...
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Sarcopenia and Neuroendocrine Neoplasms
Purpose of the ReviewTo summarise the current literature regarding the presence of sarcopenia in patients with neuroendocrine neoplasms (NENs). These...
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Systemic Therapy for Pancreatic Neuroendocrine Tumors
Pancreatic neuroendocrine tumors (PanNETs) account for approximately 2% of all pancreatic malignancies. Several systemic treatment options have been...
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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system....
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Current Management of Neuroendocrine Tumour Liver Metastases
Purpose of reviewThis article aims to illustrate the current state of investigations and management of liver metastases in patients with...
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Dyslipidemia, lipid-lowering agents and neuroendocrine neoplasms: new horizons
PurposeNeuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies originating from cells with a neuroendocrine phenotype. The complex...
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Molecular Classification of Gastrointestinal and Pancreatic Neuroendocrine Neoplasms: Are We Ready for That?
In the last two decades, the increasing availability of technologies for molecular analyses has allowed an insight in the genomic alterations of...
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Arterial function, biomarkers, carcinoid syndrome and carcinoid heart disease in patients with small intestinal neuroendocrine tumours
PurposeCarcinoid heart disease (CHD) is a life-threatening complication of carcinoid syndrome (CS) characterised by tricuspid regurgitation (TR)....
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Recent progress of experimental model in pancreatic neuroendocrine tumors: drawbacks and challenges
The neuroendocrine neoplasm, in general, refers to a heterogeneous group of all tumors originating from peptidergic neurons and neuroendocrine cells....
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Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors
As the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a...
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Where Are We Now with Liver Transplantation in Neuroendocrine Neoplasms? The Place of Liver Transplantation for Grades 1 and 2 Well-Differentiated Unresectable Liver Metastatic Neuroendocrine Tumours
Purpose of ReviewThis review outlines the role of liver transplantation in selected patients with unresectable neuroendocrine tumour liver...
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PET radiotracers for whole-body in vivo molecular imaging of prostatic neuroendocrine malignancies
AbstractProstatic neuroendocrine malignancies represent a spectrum of diseases. Treatment-induced neuroendocrine differentiation (tiNED) in...
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Characterization of zinc finger protein 536, a neuroendocrine regulator, using pan-cancer analysis
BackgroundPrevious studies suggested that zinc finger protein 536 (ZNF536) was abundant in the central brain and regulated neuronal differentiation....
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Successful management of a rare case of gallbladder neuroendocrine carcinoma with tumor thrombi
A gallbladder neuroendocrine neoplasm (GB‑NEN) is a bizarre heterogeneous neoplasm arising from neuroendocrine cells, which are present in minimal...
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Comparison of the mutational profiles of neuroendocrine breast tumours, invasive ductal carcinomas and pancreatic neuroendocrine carcinomas
The pathophysiology and the optimal treatment of breast neuroendocrine tumours (NETs) are unknown. We compared the mutational profiles of breast NETs...
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Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification
In the 2022 fifth edition of the WHO Classification of Endocrine Tumours and of Central Nervous System Tumours, pituitary adenomas are reclassified...
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Neuroendocrine disturbances in women with functional hypothalamic amenorrhea: an update and future directions
Functional hypothalamic amenorrhea (FHA) is one of the most common causes of both primary and secondary amenorrhea in women of reproductive age. It...
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Patient derived tumoroids of high grade neuroendocrine neoplasms for more personalized therapies
There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms...
