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Exosomes for neurodegenerative diseases: diagnosis and targeted therapy
Purpose of ReviewNeurodegenerative diseases are still challenging clinical issues, with no curative interventions available and early, accurate...
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Natural products in the management of neurodegenerative diseases
Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of...
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome...
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Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive...
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Extracellular protein homeostasis in neurodegenerative diseases
The protein homeostasis (proteostasis) system encompasses the cellular processes that regulate protein synthesis, folding, concentration, trafficking...
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Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases
Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, the...
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Insights into AlphaFold’s breakthrough in neurodegenerative diseases
Neurodegenerative diseases (ND) are disorders of the central nervous system (CNS) characterized by impairment in neurons’ functions, and complete...
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Healthy blood, healthy brain: a window into understanding and treating neurodegenerative diseases
Our limited understanding of complex neurodegenerative disorders has held us back on the development of efficient therapies. While several approaches...
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Modulation of Mitochondrial Function as a Therapeutic Strategy for Neurodegenerative Diseases
Despite recent FDA approval of anti-amyloid antibodies for Alzheimer’s Disease, strategies that target early molecular mechanisms and could delay or...
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G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the...
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Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist
The Condensed Protocol (CP) was originally developed for the evaluation of Alzheimer’s Disease (AD) and other neurodegenerative diseases as a...
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Applications of brain-computer interfaces in neurodegenerative diseases
Brain-computer interfaces (BCIs) provide the central nervous system with channels of direct communication to the outside world, without having to go...
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Safety of masitinib in patients with neurodegenerative diseases: a meta-analysis of randomized controlled trials
ObjectivesThis meta-analysis aimed to examine the safety of masitinib in patients with neurodegenerative diseases.
MethodsWe considered randomized...
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Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure
Most patients with late-onset neurodegenerative diseases such as Alzheimer’s and Parkinson’s have a complex aetiology resulting from numerous genetic...
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Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases
Previous observational investigations suggest that structural and diffusion imaging-derived phenotypes (IDPs) are associated with major...
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Limbic-predominant age-related TDP43 encephalopathy (LATE) neuropathological change in neurodegenerative diseases
TAR DNA-binding protein 43 (TDP43) is a focus of research in late-onset dementias. TDP43 pathology in the brain was initially identified in...
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Metabolism-related brain morphology accelerates aging and predicts neurodegenerative diseases and stroke: a UK Biobank study
Metabolic syndrome (MetS) is characterized by a constellation of metabolic risk factors, including obesity, hypertriglyceridemia, low high-density...
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Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases
Tau neurofibrillary tangles are a hallmark of Alzheimer’s disease neuropathological change. However, it remains largely unclear how distinctive...
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Clinical and MRI features of gait and balance disorders in neurodegenerative diseases
Gait and balance disorders are common signs in several neurodegenerative diseases such as Parkinson’s disease, atypical parkinsonism, idiopathic...
