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Circulating Markers of Necroptosis in Acute Pancreatitis
ObjectivesNecroptosis, a programmed inflammatory cell death, is involved in the pathogenesis of acute pancreatitis (AP). We compared levels of...
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The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains....
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Role of necroptosis in kidney health and disease
Cell death, particularly that of tubule epithelial cells, contributes critically to the pathophysiology of kidney disease. A body of evidence...
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JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway
BackgroundAcute kidney injury (AKI), characterized by necroptosis and activation of MAPK pathway, causes sudden declines in renal function. To date,...
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Role of necroptosis and immune infiltration in preeclampsia: novel insights from bioinformatics analyses
BackgroundPreeclampsia (PE) is a serious pregnancy complication that can adversely affect the mother and fetus. Necroptosis is a recently discovered...
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Necroptosis-related lncRNA-based novel signature to predict the prognosis and immune landscape in soft tissue sarcomas
BackgroundNecroptosis-related long noncoding RNAs (lncRNAs) play crucial roles in cancer initiation and progression. Nevertheless, the role and...
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Potential therapeutic value of necroptosis inhibitor for the treatment of COVID-19
The coronavirus disease 2019 (COVID-19), caused by a novel virus of the beta-coronavirus genus (SARS-CoV-2), has spread rapidly, posing a significant...
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Necroptosis-related genes are associated with prognostic features of kidney renal clear cell carcinoma
IntroductionRenal clear cell carcinoma is a common type of cancer in the adult urological system. It has a high mortality rate, with 30% of patients...
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Signatures of necroptosis-related genes as diagnostic markers of endometriosis and their correlation with immune infiltration
BackgroundEndometriosis (EMS) occurs when normal uterine tissue grows outside the uterus and causes chronic pelvic pain and infertility....
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Metformin attenuates lung ischemia-reperfusion injury and necroptosis through AMPK pathway in type 2 diabetic recipient rats
BackgroundDiabetes mellitus (DM) can aggravate lung ischemia-reperfusion (I/R) injury and is a significant risk factor for recipient mortality after...
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Osteoking promotes bone formation and bone defect repair through ZBP1–STAT1–PKR–MLKL-mediated necroptosis
BackgroundOsteoking has been used for fracture therapy with a satisfying clinical efficacy. However, its therapeutic properties and the underlying...
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Major adverse cardiovascular events are associated with necroptosis during severe COVID-19
BackgroundThe mechanisms used by SARS-CoV-2 to induce major adverse cardiac events (MACE) are unknown. Thus, we aimed to determine if SARS-CoV-2 can...
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A prognostic model based on necroptosis-related genes for prognosis and therapy in bladder cancer
Bladder cancer, one of the most prevalent malignant cancers, has high rate of recurrence and metastasis. Owing to genomic instability and high-level...
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A comprehensive analysis of the potential role of necroptosis in hepatocellular carcinoma using single-cell RNA Seq and bulk RNA Seq
PurposeNecroptosis plays an essential role in oncogenesis and tumor progression in hepatocellular carcinoma (HCC). This study aimed to investigate...
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Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment....
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Identification and Validation a Necroptosis-Related Prognostic Signature in Cervical Cancer
Necroptosis is a promising novel target for cervical cancer therapy. Nevertheless, differentially expressed necroptosis-related genes (NRGs) in...
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Butyrate induces development-dependent necrotizing enterocolitis-like intestinal epithelial injury via necroptosis
BackgroundThe accumulation of short-chain fatty acids (SCFAs) from bacterial fermentation may adversely affect the under-developed gut as observed in...
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Comprehensive analysis of necroptosis-related lncRNA signature with potential implications in tumor heterogeneity and prediction of prognosis in clear cell renal cell carcinoma
BackgroundNecroptosis has been reported to play a critical role in occurrence and progression of cancer. The dysregulation of long non-coding RNAs...
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Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer
BackgroundNecroptosis is a novel type of programmed cell death distinct from apoptosis. However, the role of necroptosis in ovarian cancer (OC)...
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Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala
Aging is characterized with a progressive decline in many cognitive functions, including behavioral flexibility, an important ability to respond...
