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The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families
ObjectivesComponents of the hypothalamic-pituitary axis (HPA) pathway are potential mediators of the genetic risk of polycystic ovarian syndrome...
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Association between academic pressure, NR3C1 gene methylation, and anxiety symptoms among Chinese adolescents: a nested case-control study
BackgroundAcademic pressure is a prevalent stressor among Chinese adolescents and is often linked to anxiety symptoms, although the underlying...
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Glucocorticoid receptor (NR3C1) genetic polymorphisms and the outcomes of sudden sensorineural hearing loss
BackgroundThe glucocorticoid receptor gene ( NR3C1 ) encodes the receptor to which cortisol and other glucocorticoids bind. Steroids in either oral,...
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Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy
Epigenetic processes allow plasticity in gene regulation in response to significant environmental events. Accumulating evidence suggests that...
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Decreased mononuclear cell NR3C1 SKA2 and FKPB5 expression levels among adult survivors of suicide bombing terror attacks in childhood are associated with the development of PTSD
Life threatening trauma and the development of PTSD during childhood, may each associate with transcriptional perturbation of immune cell...
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Maternal and infant NR3C1 and SLC6A4 epigenetic signatures of the COVID-19 pandemic lockdown: when timing matters
Stress exposure during pregnancy is critically linked with maternal mental health and child development. The effects might involve altered patterns...
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The association between glucocorticoid receptor (NR3C1) gene polymorphism and difficult-to-treat rhinosinusitis
BackgroundDifficult-to-treat rhinosinusitis (DTRS) seriously affects the quality of work and life of patients, and the cause is still unclear. We...
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The interplay between genetic variation and gene expression of the glucocorticoid receptor gene NR3C1 and blood cortisol levels on verbal memory and hippocampal volumes
The hypothalamus–pituitary–adrenal axis is the main physiological stress response system and regulating the release of cortisol. The two corticoid...
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Prenatal earthquake stress exposure in different gestational trimesters is associated with methylation changes in the glucocorticoid receptor gene (NR3C1) and long-term working memory in adulthood
Prenatal stress exposure is thought to affect the long-term development of the foetal brain via the HPA axis and to change health outcomes in...
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Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene
The genomic effects of circulating glucocorticoids are particularly relevant in cortico-limbic structures, which express a high concentration of...
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CPEB3-dowregulated Nr3c1 mRNA translation confers resilience to develo** posttraumatic stress disorder-like behavior in fear-conditioned mice
Susceptibility or resilience to posttraumatic stress disorder (PTSD) depends on one’s ability to appropriately adjust synaptic plasticity for co**...
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Resting mononuclear cell NR3C1 and SKA2 expression levels predict blunted cortisol reactivity to combat training stress among elite army cadets exposed to childhood adversity
Childhood adversity (CA) may alter reactivity to stress throughout life, increasing risk for psychiatric and medical morbidity, yet long-term...
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Glucocorticoid receptor gene (NR3C1) is hypermethylated in adult males with aggressive behaviour
Aggressive behaviour is a serious threat to the personal safety and property of others due to the potential that the assailant may hurt people,...
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11-beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene expression in muscle is linked to reduced skeletal muscle index in sarcopenic patients
BackgroundGlucocorticoids play a significant role in metabolic processes and pathways that impact muscle size, mass, and function. The expression of...
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The role of glucocorticoid receptor gene in the association between attention deficit-hyperactivity disorder and smaller brain structures
ADHD is associated with smaller subcortical brain volumes and cortical surface area, with greater effects observed in children than adults. It is...
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DNA methylation of the glucocorticoid receptor gene predicts substance use in adolescence: longitudinal data from over 1000 young individuals
Early life stress has been linked to increased methylation of the Nuclear Receptor Subfamily 3 Group C Member 1 ( NR3C1 ) gene, which codes for the...
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Effects of antidepressant on FKBP51 mRNA expression and neuroendocrine hormones in patients with panic disorder
ObjectiveThe purpose of this study was to investigate the effects of escitalopram on the peripheral expression of hypothalamic-pituitary-adrenal...
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Black Mothers in Racially Segregated Neighborhoods Embodying Structural Violence: PTSD and Depressive Symptoms on the South Side of Chicago
This study employs multi-level and mixed-methods approaches to examine how structural violence affects the health of low-income, single Black...
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Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid. Few treatments exist to reduce comorbid PTSD/AUD....
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Effect of strontium on transcription factors identified by transcriptome analyses of bovine ruminal epithelial cells
BackgroundStrontium (Sr) has similar physicochemical properties as calcium (Ca) and is often used to evaluate the absorption of this mineral. Because...
