Search
Search Results
-
FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development
Stem/progenitor cells differentiate into different cell lineages during organ development and morphogenesis. Signaling pathway networks and...
-
Phase separation in cGAS-STING signaling
Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes....
-
TGF-β signaling in health, disease, and therapeutics
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The signal transduction of TGF-β can...
-
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved...
-
Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies
The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling...
-
Statins repress hedgehog signaling in medulloblastoma with no bone toxicities
The Hedgehog (Hh) pathway plays an indispensable role in bone development and genetic activation of the pathway results in medulloblastoma (MB), the...
-
Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states
Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal and synaptic physiology. Astrocytic alterations have been...
-
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell...
-
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was...
-
Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models
Purpose of ReviewTo illustrate the value of using zebrafish to understand the role of the Fgf signaling pathway during craniofacial skeletal...
-
Interferon-gamma signaling promotes melanoma progression and metastasis
Interferon-gamma (IFNG) has long been regarded as the flag-bearer for the anti-cancer immunosurveillance mechanisms. However, relatively recent...
-
Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject...
-
ACh signaling modulates activity of the GABAergic signaling network in the basolateral amygdala and behavior in stress-relevant paradigms
The balance between excitatory and inhibitory (E/I) signaling is important for maintaining homeostatic function in the brain. Indeed, dysregulation...
-
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions
Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research,...
-
Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype
TP53 and RB1 loss-of-function mutations are common in osteosarcoma. During development, combined loss of TP53 and RB1 function leads to...
-
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent...
-
PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
The over-activation of ERα signaling is regarded as the major driver for luminal breast cancers, which could be effective controlled via selective...
-
A clinicopathological exploration of Hedgehog signaling: implications in oral carcinogenesis
IntroductionHedgehog Signaling, a basic cancer stem cell pathway, plays a major role during the embryonic development, is known to play a quiescent...
-
p38 Signaling Mediates Naringin-Induced Osteogenic Differentiation of Porcine Metanephric Mesenchymal Cells
ObjectiveTo explore the potential of metanephric mesenchymal cells (MMCs) for osteogenesis and naringin’s ability to enhance this process and its...
-
Natural products targeting the MAPK-signaling pathway in cancer: overview
PurposeThis article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures,...
