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Suppression of CD56bright NK cells in breast cancer patients is associated with the PD-1 and TGF-βRII expression
BackgroundNatural killer (NK) cells, as professional cytotoxic cells, play a key role against cancer in the early and metastatic stages. Their...
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PD-1 expression, among other immune checkpoints, on tumor-infiltrating NK and NKT cells is associated with longer disease-free survival in treatment-naïve CRC patients
A variety of variables, such as microsatellite instability or inflammatory mediators, are critical players in the development and progression of...
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NK cell transfer overcomes resistance to PD-(L)1 therapy in aged mice
BackgroundCancer is the leading cause of death among older adults. Although the integration of immunotherapy has revolutionized the therapeutic...
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High co-expression of immune checkpoint receptors PD-1, CTLA-4, LAG-3, TIM-3, and TIGIT on tumor-infiltrating lymphocytes in early-stage breast cancer
High expression of immune checkpoint receptors (ICRs) in the tumor microenvironment regulates the anti-tumor response. In this study, the...
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Increased TIM-3+PD-1+ NK cells are associated with the disease activity and severity of systemic lupus erythematosus
It is well established that natural killer (NK) cells are dysregulated in systemic lupus erythematosus (SLE) patients. However, the functions of NK...
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Programmable synthetic receptors: the next-generation of cell and gene therapies
Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat diseases. However, concerns over the safety and efficacy...
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Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells
Natural killer (NK) cells are cytotoxic innate lymphocytes that are specialized to kill tumor cells. NK cells are responsive to the primary cytokine...
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The role of histamine and its receptors in breast cancer: from pathology to therapeutic targets
Breast cancer is the most common malignancy in women, and despite the development of new treatment methods and the decreasing mortality rate in...
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CD56bright NK cell expansion correlated with EBV reactivation control post allogeneic hematopoietic stem cell transplantation
Natural killer (NK) cells are equipped with anti-Epstein-Barr virus (EBV) function, however, whether EBV infection will affect NK cells...
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Therapeutic applications of toll-like receptors (TLRs) agonists in AML
Acute myeloid leukemia (AML) is an aggressive type of blood cancer affecting bone marrow (BM). In AML, hematopoietic precursors are arrested in the...
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Cancer-biomarkers associated with sex hormone receptors and recent therapeutic advancements: a comprehensive review
Hormones and its regulation plays vital role in causing breast, prostate, ovarian and endometrial cancers collectively known as hormone-sensitive...
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The role of toll-like receptors (TLRs) and their therapeutic applications in glomerulonephritis
One of the most important features of innate immunity is the presence of a special group of pattern recognition receptors (PRRs) called toll-like...
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CC chemokines and receptors in osteoarthritis: new insights and potential targets
Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of innate and adaptive immune systems-associated inflammatory...
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Inhibitory receptors for HLA class I as immune checkpoints for natural killer cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy
Natural killer (NK) cells mediate potent anti-tumor responses, which makes them attractive targets for immunotherapy. The anti-tumor response of...
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Reactivation of natural killer cells with monoclonal antibodies in the microenvironment of malignant neoplasms
Natural killer cells are critical players in the antitumor immune response due to their ability to destroy target cells through cytotoxic activity...
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Refurbishment of NK cell effector functions through their receptors by depleting the activity of nTreg cells in Dalton’s Lymphoma-induced tumor microenvironment: an in vitro and in vivo study
Natural killer (NK) cells play a crucial role in the anti-tumor transaction through cytolytic activity with the help of proportionate expression of...
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Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension
BackgroundPulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH), is a type of pulmonary vascular disease characterized by...
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Therapeutic applications of engineered chimeric antigen receptors-T cell for cancer therapy
BackgroundFindings of new targeted treatments with adequate safety evaluations are essential for better cancer cures and mortality rates....
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Altered expression of cytokines, chemokines, growth factors, and soluble receptors in patients with colorectal cancer, and correlation with treatment outcome
Insofar as they play an important role in the pathogenesis of colorectal cancer (CRC), this study analyzes the serum profile of cytokines,...
