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Impact of immune checkpoint inhibitors (ICIs) therapy on interferon-γ release assay (IGRA) and diagnostic value in non-small cell lung cancer (NSCLC) patients
BackgroundTuberculosis (TB), a highly contagious respiratory disease, presents a significant global health threat, with a notable increase in...
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Ashwagandha root extract’s phenolic compound counteracts alloxan’s effects on oxidative stress, inflammatory cytokines, and peripheral neuropathy in rats
Despite advances in understanding the intricate pathophysiological mechanisms underlying peripheral nerve injury, there are still few proven cures....
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Clinical and Laboratory Profiles of 17 Cases of Chronic Granulomatous Disease in North India
A primary immune deficiency disorder is often suspected in children with recurrent deep seated and fungal infections and those admitted to...
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Clinical Utility of Sperm Function Tests in Predicting Male Fertility: A Systematic Review
Routine semen analysis provides considerable information regarding sperm parameters; however, it is not solely adequate to predict male fertility...
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MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression
Stimulating bone formation potentially suggests therapeutics for orthopedic diseases including osteoporosis and osteoarthritis. Osteoblasts are key...
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Effects of matcha tea extract on cell viability and estrogen receptor-β expression on MCF-7 breast cancer cells
PurposeIn the following work, we investigated the effect of matcha green tea extract (MTE) on MCF-7 breast cancer cell viability and estrogen...
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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor...
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SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition
Despite the promising antitumor activity of SHP2 inhibitors in RAS-dependent tumours, overall responses have been limited by their narrow therapeutic...
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Accuracy of a reverse dot blot hybridization assay for simultaneous detection of the resistance of four anti-tuberculosis drugs in Mycobacterium tuberculosis isolated from China
BackgroundDrug resistant tuberculosis poses a great challenge for tuberculosis control worldwide. Timely determination of drug resistance and...
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WAC, a novel GBM tumor suppressor, induces GBM cell apoptosis and promotes autophagy
WAC is closely related to the occurrence and development of tumors. However, its role in human glioblastoma (GBM) and its potential regulatory...
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Shuangshen Ningxin capsule alleviates myocardial ischemia–reperfusion injury in miniature pigs by modulating mitophagy: network pharmacology and experiments in vivo
BackgroundMyocardial ischemia/reperfusion injury (MI/RI) is involved in a variety of pathological states for which there is no effective treatment...
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Antioxidant properties and cytotoxic effects of Oxalis corniculata on human Hepatocarcinoma (Hep-G2) cell line: an in vitro and in silico evaluation
BackgroundOxalis corniculata is a well-known medicinal plant used in folk medicine for the management of many diseases. The aim is to determine the...
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Alamandine attenuates ovariectomy-induced osteoporosis by promoting osteogenic differentiation via AMPK/eNOS axis
BackgroundAlamandine is a newly characterized peptide of renin angiotensin system. Our study aims to investigate the osteo-preservative effects of...
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A fludarabine and melphalan reduced-intensity conditioning regimen for HSCT in fifteen chronic granulomatous disease patients and a literature review
Chronic granulomatous disease (CGD) is a life-threatening immunodeficiency condition. To date, hematopoietic stem cell transplantation (HSCT) is the...
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LncRNA NEAT1 knockdown ameliorates LPS-induced human kidney injury by mediating the miR-330-5p/FOXO3 axis
BackgroundSepsis is a systemic process with multiple inflammatory responses and organ injuries, particularly in the damage of the kidney. Recently,...
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Integrating in silico molecular docking, ADMET analysis of C.verticillata with diabetic markers and in vitro anti-inflammatory activity
BackgroundOver the past decade, various research studies have proved the interconnection between the inflammatory pathways and diabetes complication...
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Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration
BackgroundTreatment of methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections in implant placement surgery is limited by the lack of...
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Persistent Pneumonia in an Infant
An eight month old boy presented with a subacute febrile illness and radiological evidence of multifocal cavitatory consolidations in the lungs. He...
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PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B
PRMT6, a type I arginine methyltransferase, di-methylates the arginine residues of both histones and non-histones asymmetrically. Increasing evidence...
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An esculentin-1 homolog from a dark-spotted frog (Pelophylax nigromaculatus) possesses antibacterial and immunoregulatory properties
BackgroundEsculentin-1, initially discovered in the skin secretions of pool frogs ( Pelophylax lessonae ), has demonstrated broad-spectrum...
