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A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference
Recent evidence links synaptic plasticity and mRNA translation, via the eukaryotic elongation factor 2 kinase (eEF2K) and its only known substrate,...
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CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors
As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by deficits in language...
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Sub-muscular Reconstruction after NAC Sparing Mastectomy: Direct to Implant Breast Reconstruction with Human ADM Versus Tissue Expander
BackgroundNipple areola complex (NAC) sparing mastectomy allows good oncological and aesthetic results. The study compares the results, in terms of...
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Transaxillary Single-Port Endoscopic Nipple-Sparing Mastectomy with Immediate Implant-based Breast Reconstruction in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy or Not: A Comparative Study with Analysis of Surgical Complications and Patient-Reported Outcomes
BackgroundIn most cases, transaxillary single-port endoscopic nipple-sparing mastectomy with immediate implant-based breast reconstruction...
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Analysis of plasma HER2 copy number in cell-free DNA of breast cancer patients: a comparison with HER2 extracellular domain protein level in serum
BackgroundHER2 (human epidermal growth factor receptor 2) status has been evaluated in breast cancer (BC) tissues by immunohistochemistry or in situ...
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Association between N-acetylcysteine treatment and in-hospital mortality in adult patients with acquired thrombotic thrombocytopenic purpura: a cohort study
Acquired thrombotic thrombocytopenic purpura (aTTP) is a fatal hematologic disease. Despite the currently high standards of care, some patients who...
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N-Acetylcistein for thrombotic thrombocytopenic purpura: an observational case series study
Acquired thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder. N-Acetylcysteine (NAC) rapidly degrades ultra-large von Willebrand...
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Diagnostic performance of MRI for assessing axillary lymph node status after neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis
ObjectiveThis systematic review examined the diagnostic performance of magnetic resonance imaging (MRI) for assessing axillary lymph node status...
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Hepatoprotective effects of N-acetylcysteine on liver injury by irisin upregulation and oxidative stress reduction in diabetic rats
BackgroundThe current study aimed to investigate the oxidative stress in rat liver with diabetes mellitus (DM) as well as the protective effects of...
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Transfer learning-based attenuation correction for static and dynamic cardiac PET using a generative adversarial network
PurposeThe goal of this work is to demonstrate the feasibility of directly generating attenuation-corrected PET images from non-attenuation-corrected...
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Ultrasound-based radiomics for early predicting response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review with meta-analysis
ObjectiveThis study aims to evaluate the diagnostic accuracy of ultrasound imaging (US)-based radiomics for the early prediction of response to...
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Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice
Use of the synthetic opioid fentanyl increased ~300% in the last decade, including among women of reproductive ages. Adverse neonatal outcomes and...
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Pretreatment ultrasound-based deep learning radiomics model for the early prediction of pathologic response to neoadjuvant chemotherapy in breast cancer
ObjectivesTo investigate the predictive performance of the deep learning radiomics (DLR) model integrating pretreatment ultrasound imaging features...
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Development and validation of peritumoral vascular and intratumoral radiomics to predict pathologic complete responses to neoadjuvant chemotherapy in patients with triple-negative breast cancer
BackgroundTo develop and validate a peritumoral vascular and intratumoral radiomics model to improve pretreatment predictions for pathologic complete...
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Bdnf-Nrf-2 crosstalk and emotional behavior are disrupted in a sex-dependent fashion in adolescent mice exposed to maternal stress or maternal obesity
Maternal obesity has been recognized as a stressor affecting the develo** fetal brain, leading to long-term negative outcomes comparable to those...
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Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer
BackgroundPlatinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently...
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N-acetyl cysteine as a potential regulator of SARS-CoV-2-induced male reproductive disruptions
BackgroundThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), has shown its persistent...
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Predicting Soft Tissue Sarcoma Response to Neoadjuvant Chemotherapy Using an MRI-Based Delta-Radiomics Approach
ObjectivesTo evaluate the performance of machine learning–augmented MRI-based radiomics models for predicting response to neoadjuvant chemotherapy...
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TP53-positive clones are responsible for drug-tolerant persister and recurrence of HER2-positive breast cancer
PurposeThe prognosis of HER2-positive breast cancer has improved with the development of anti-HER2 therapies. In order to further improve the...
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The psychometric properties of a caregiving-related strain scale in oncology
BackgroundCaregivers are rarely assessed for caregiving-related strain. This study explored the psychometric properties of the caregiving-related...