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Cortical glutamate, Glx, and total N-acetylaspartate: potential biomarkers of repetitive transcranial magnetic stimulation treatment response and outcomes in major depression
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for individuals with major depressive disorder (MDD) who have not...
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Serine, N-acetylaspartate differentiate adolescents with juvenile idiopathic arthritis compared with healthy controls: a metabolomics cross-sectional study
BackgroundIn comparison with the general population, adolescents with juvenile idiopathic arthritis (JIA) are at higher risk for morbidity and...
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Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy
BackgroundIncreased extracellular glutamate is known to cause epileptic seizures in patients with glioblastoma (GBM). However, predicting whether the...
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Metabolic changes assessed by 1H MR spectroscopy in the corpus callosum of post-COVID patients
ObjectiveMany patients with long COVID experience neurological and psychological symptoms. Signal abnormalities on MR images in the corpus callosum...
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Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients
BackgroundNeuropsychiatric manifestations of lupus (NPSLE) are considered one of the major and most devastating lupus manifestations. The aim of this...
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Smoking, tobacco dependence, and neurometabolites in the dorsal anterior cingulate cortex
Cigarette smoking has a major impact on global health and morbidity, and positron emission tomographic research has provided evidence for reduced...
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Rate of abnormalities in quantitative MR neuroimaging of persons with chronic traumatic brain injury
BackgroundMild traumatic brain injury (mTBI) can result in lasting brain damage that is often too subtle to detect by qualitative visual inspection...
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Neurometabolic changes in neonates with congenital heart defects and their relation to neurodevelopmental outcome
BackgroundAltered neurometabolite ratios in neonates undergoing cardiac surgery for congenital heart defects (CHD) may serve as a biomarker for...
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The full spectrum of MRI findings in 18 patients with Canavan disease: new insights into the areas of selective susceptibility
IntroductionCanavan disease (CD) is a rare autosomal recessive neurodegenerative disorder caused by a deficiency of aspartoacylase A, an enzyme that...
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Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia
The neurobiological effects of clozapine are under characterised. We examined the effects clozapine treatment on subcortical volume and cortical...
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Persistent neuroinflammation of the right insular cortex in children with juvenile idiopathic arthritis: a proton MRS study
ObjectiveThe aim of this study of children with juvenile idiopathic arthritis (JIA) was to use proton magnetic resonance spectroscopy ( 1 H-MRS) to...
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Brain metabolite alterations related to alcohol use: a meta-analysis of proton magnetic resonance spectroscopy studies
Alcohol misuse and alcohol use disorder (AlUD) have neurobiological consequences. This meta-analysis of proton magnetic resonance spectroscopy (MRS)...
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Neurochemical properties measured by 1H magnetic resonance spectroscopy may predict cognitive behaviour therapy outcome in paediatric OCD: a pilot study
To identify neurochemical factors measured pre-treatment that may predict cognitive behavioural treatment (CBT) outcome, aiming at understanding...
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Alterations in metabolites in the anterior cingulate cortex and thalamus and their associations with pain and empathy in patients with chronic mild pain: a preliminary study
Proton magnetic resonance spectroscopy ( 1 H-MRS) has shown inconsistent alterations in the brain metabolites of individuals with chronic pain. We used...
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Cerebral monitoring in a pig model of cardiac arrest with 48 h of intensive care
BackgroundNeurological injury is the primary cause of death after out-of-hospital cardiac arrest. There is a lack of studies investigating cerebral...
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Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
Over the last five decades, a large body of evidence has accrued for structural and metabolic brain alterations in schizophrenia. Here we provide an...
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Evidence of persistent glial cell dysfunction in the anterior cingulate cortex of juvenile idiopathic arthritis children: a proton MRS study
BackgroundThis study aims to investigate whether the neurometabolites of the anterior cingulate cortex (ACC) were distinct in patients with active...
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Microstructural and Metabolic Changes in Normal Aging Human Brain Studied with Combined Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging
PurposeThis study aimed to detect age-related brain metabolic and microstructural changes in healthy human brains by the use of whole-brain proton...
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Evaluation of the diagnostic utility on 1.5T and 3.0T 1H magnetic resonance spectroscopy for temporal lobe epilepsy
Background1 H magnetic resonance spectroscopy ( 1 H-MRS) can be used to study neurological disorders because it can be utilized to examine the...
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Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder
Psilocybin has shown promise for the treatment of mood disorders, which are often accompanied by cognitive dysfunction including cognitive rigidity....
