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Blood–brain barrier dysfunction and myelin basic protein in survival of amyotrophic lateral sclerosis with or without frontotemporal dementia
ObjectiveWe aim to investigate blood–brain barrier (BBB) dysfunction and myelin basic protein (MBP) in amyotrophic lateral sclerosis (ALS) with or...
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Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury
The aim of this study was to investigate if the biomarkers myelin basic protein (MBP) and neurofilament-H (NF-H) yielded informative value in...
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Role of fenofibrate in multiple sclerosis
Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the central nervous system (CNS). The underlying...
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Measuring Pathology in Patients with Multiple Sclerosis Using Positron Emission Tomography
Purpose of ReviewMultiple sclerosis is characterized by a diverse and complex pathology. Clinical relapses, the hallmark of the disease, are...
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FcRn Inhibitor Therapies in Neurologic Diseases
In the last decade, the landscape of treating autoimmune diseases has evolved with the emergence and approval of novel targeted therapies. Several...
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Molecular biomarkers for vascular cognitive impairment and dementia
As disease-specific interventions for dementia are being developed, the ability to identify the underlying pathology and dementia subtypes is...
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Beneficial effects of ferulic acid in streptozotocin-induced diabetic neuropathy in male Wistar rats
ObjectivesThe available medications for diabetes mellitus (DM) are not sufficient to reverse the pathophysiological abnormalities and complications...
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Chronic Demyelination and Axonal Degeneration in Multiple Sclerosis: Pathogenesis and Therapeutic Implications
Purpose of ReviewMultiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). Inflammatory attacks in MS...
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White matter damage as a consequence of vascular dysfunction in a spontaneous mouse model of chronic mild chronic hypoperfusion with eNOS deficiency
Vascular cognitive impairment and dementia (VCID) is the second most common form of dementia after Alzheimer’s disease (AD). Currently, the...
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Targeting the brain 5-HT7 receptor to prevent hypomyelination in a rodent model of perinatal white matter injuries
Approximately 15 million babies are born prematurely every year and many will face lifetime motor and/or cognitive deficits. Children born...
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Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis
In multiple sclerosis (MS), sustained inflammatory activity can be visualized by iron-sensitive magnetic resonance imaging (MRI) at the edges of...
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AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia
Chronic cerebral hypoperfusion is associated with vascular dementia (VaD). Cerebral hypoperfusion may initiate complex molecular and cellular...
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Endothelial cells and macrophages as allies in the healthy and diseased brain
Diseases of the central nervous system (CNS) are often associated with vascular disturbances or inflammation and frequently both. Consequently,...
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The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology
Although the pathology of X-linked adrenoleukodystrophy (ALD) is well described, it represents the end-stage of neurodegeneration. It is still...
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Determining Commonalities in the Experiences of Patients with Rare Diseases: A Qualitative Analysis of US Food and Drug Administration Patient Engagement Sessions
BackgroundRare diseases are estimated to affect more than one in ten Americans. However, most patients with a rare disease face significant...
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Amyloid PET scan diagnosis of Alzheimer’s disease in patients with multiple sclerosis: a sco** review study
BackgroundMultiple sclerosis (MS) is an autoimmune disease affecting the central nervous system. This study aimed to evaluate the advantages and...
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Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage
ObjectiveIntracerebral hemorrhage (ICH) refers to predominant, sporadic, and non-traumatic bleeding in the brain parenchyma. The PI3K/AKT/mTOR...
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Biochemical analyses for dental age estimation: a review
BackgroundFor various legal and forensic scenarios, establishing an individual’s age, both living and dead, plays a crucial role. Various...
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An Update on Diagnostic Laboratory Biomarkers for Multiple Sclerosis
PurposeFor many patients, the multiple sclerosis (MS) diagnostic process can be lengthy, costly, and fraught with error. Recent research aims to...
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The Role of Gut Dysbiosis and Potential Approaches to Target the Gut Microbiota in Multiple Sclerosis
It has now been established that a perturbation in gut microbiome composition exists in multiple sclerosis (MS) and its interplay with the immune...