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Multivariate analysis of PET pharmacokinetic parameters improves inferential efficiency
PurposeIn positron emission tomography quantification, multiple pharmacokinetic parameters are typically estimated from each time activity curve....
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Emotion regulation in bipolar disorder type-I: multivariate analysis of fMRI data
BackgroundBipolar disorder type-I (BD-I) patients are known to show emotion regulation abnormalities. In a previous fMRI study using an explicit...
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Identifying causal associations between women’s reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis
BackgroundA significant association between women’s reproductive traits and the risk of schizophrenia (SCZ) has been discovered, but the causalities...
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Development and validation of a Context-sensitive Positive Health Questionnaire (CPHQ): A factor analysis and multivariate regression study
BackgroundThe concept of Positive Health (PH) has gained increasing attention as a way of measuring individuals’ ability to adapt in the face of...
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Multivariate meta-analysis of multiple outcomes: characteristics and predictors of borrowing of strength from Cochrane reviews
ObjectivesMultivariate meta-analysis allows the joint synthesis of multiple outcomes accounting for their correlation. This enables borrowing of...
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Markets matter: a simulation study of the bias-variance trade-off in comparison group selection for difference-in-differences analysis
Recent research reveals many pitfalls when selecting a comparison group for difference-in-differences analyses of observational data. Recommendations...
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CT-based analysis of sagittal and coronal lumbar endplate morphology: multivariate analysis of factors associated with endplate depth
PurposeLumbar endplate morphology varies in individuals; thus, custom-made implants are sometimes more useful than standardized implants. This study...
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Association between biomarkers of redox status and cytokines with different patterns of habitual physical activity in eutrophic and overweight/obese preschoolers: multivariate analysis of a cross-sectional study
BackgroundAlthough it is well known that obesity is frequently associated with reduced levels of habitual physical activity (HPA), which contributes...
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Multivariate brain-behaviour associations in psychiatric disorders
Map** brain-behaviour associations is paramount to understand and treat psychiatric disorders. Standard approaches involve investigating the...
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Tracking the effect of roasting and fermentation on the metabolites of licorice root (Glycyrrhiza glabra L.) using UPLC-MS analysis combined with multivariate statistical analysis
BackgroundRoasting, honey-roasting and fermentation are the most common pre-processing procedures of licorice roots. They were shown to noticeably...
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Raman spectroscopy combined with multivariate statistical algorithms for the simultaneous screening of cervical and breast cancers
Breast and cervical cancers are becoming the leading causes of death among women worldwide, but current diagnostic methods have many drawbacks, such...
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Multivariate analysis of independent determinants of ADL/IADL and quality of life in the elderly
BackgroundThis study evaluated the determinants of disability and quality of life in elderly people who participated at the multi-centred RubiN...
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Bi-directional and multivariate mendelian randomization analysis of the relationship between circulating 25-hydroxyvitamin D concentration and obstructive sleep apnea
Background25-hydroxyvitamin D [25(OH)D] deficiency in patients with Obstructive Sleep Apnea (OSA) has long been noted, but identifying the exact...
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Residence-based inequalities in overweight/obesity in sub-Saharan Africa: a multivariate non-linear decomposition analysis
BackgroundOverweight/obesity remains a major risk factor for non-communicable diseases and their associated morbidities and mortalities. Yet, limited...
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High consumption of soft drinks and perceptions of consumption among university students: A multivariate analysis with a machine learning (ML) algorithm
IntroductionSoft drinks, defined as liquids with added sugar and artificial flavorings, have become increasingly popular among the people of...
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Risk factors for postoperative sympathetic chain dysfunction following oblique lateral lumbar interbody fusion: a multivariate analysis
PurposePostoperative sympathetic chain dysfunction (PSCD) was a relatively common complication after anterior lumbar interbody fusion due to the...
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Negative log-binomial model with optimal robust variance to estimate the prevalence ratio, in cross-sectional population studies
BackgroundCross-sectional studies are useful for the estimation of prevalence of a particular event with concerns in specific populations, as in the...
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Multivariate patterns of brain functional connectome associated with COVID-19-related negative affect symptoms
Severe mental health problems with the representation of negative affect symptoms (NAS) have been increasingly reported during the coronavirus...
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Causal effects of glycemic traits and endometriosis: a bidirectional and multivariate mendelian randomization study
BackgroundObservational studies have suggested an association between endometriosis and glycemic traits, but causality remains unclear. We used...
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Metabolic profiling of milk thistle different organs using UPLC-TQD-MS/MS coupled to multivariate analysis in relation to their selective antiviral potential
IntroductionSilybum marianum commonly known as milk thistle is one of the most imperative medicinal plants due to its remarkable pharmacological...