Search
Search Results
-
Using Power Analysis to Choose the Unit of Randomization, Outcome, and Approach for Subgroup Analysis for a Multilevel Randomized Controlled Clinical Trial to Reduce Disparities in Cardiovascular Health
We give examples of three features in the design of randomized controlled clinical trials which can increase power and thus decrease sample size and...
-
Community Walks: a cluster randomized controlled trial of a multilevel physical activity intervention for low income public housing residents
BackgroundPhysical activity behavioral interventions to change individual-level drivers of activity, like motivation, attitudes, and self-efficacy,...
-
A multilevel intervention to promote HPV vaccination among young adults in Texas: protocol for a randomized controlled trial
BackgroundHuman papillomavirus (HPV) infections can cause cancers of the cervix, vagina, vulva, penis, anus, and oropharynx. The most recently...
-
A Hybrid Pragmatic and Factorial Cluster Randomized Controlled Trial for an Anti-racist, Multilevel Intervention to Improve Mental Health Equity in High Schools
Systemic racism is pervasive in US society and disproportionately limits opportunities for education, work, and health for historically marginalized...
-
The efficacy and safety of intravenous tranexamic acid in patients with posterior operation of multilevel thoracic spine stenosis: a prospective randomized controlled trial
BackgroundThis study was a randomized controlled trial to evaluate efficacy and safety of the usage of intravenous tranexamic acid during posterior...
-
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Background and ObjectivesConcerns exist regarding the rising use of methylphenidate. A double-blind, placebo-controlled methylphenidate titration...
-
Short-term effects of the strengthening families Program (SFP 10–14) in Brazil: a cluster randomized controlled trial
IntroductionThis study reports the evaluation of the short-term effects of the Strengthening Families Program (SFP 10–14), adapted as Famílias Fortes ...
-
Impact of an INtervention to increase MOBility in older hospitalized medical patients (INTOMOB): Study protocol for a cluster randomized controlled trial
BackgroundLow mobility during an acute hospitalization is frequent and associated with adverse effects, including persistent functional decline,...
-
Health effects and cost-effectiveness of a multilevel physical activity intervention in low-income older adults; results from the PEP4PA cluster randomized controlled trial
BackgroundOlder adults are the least active population in the U.S. Low-income communities have fewer physical activity (PA) resources, contributing...
-
Personalized exposure and experience sampling method feedback versus exposure as usual for obsessive–compulsive disorder: a study protocol for a randomized controlled trial
BackgroundPatients with obsessive–compulsive disorder (OCD) suffer from repetitive fearful intrusions which they try to neutralize by performing...
-
Transdiagnostic and tailored internet intervention to improve mental health among university students: Research protocol for a randomized controlled trial
BackgroundEmerging adulthood is often associated with mental health problems. About one in three university students report symptoms of depression...
-
Improving symptom management for survivors of young adult cancer: rationale and study protocol for a pilot randomized controlled trial
BackgroundYoung adult (YA) cancer survivors are a growing, yet underserved population who often face significant and long-lasting cancer-related...
-
Systems analysis and improvement approach to improve naloxone distribution within syringe service programs: study protocol of a randomized controlled trial
BackgroundMore than half a million Americans died of an opioid-related overdose between 1999 and 2020, the majority occurring between 2015 and 2020....
-
Principle-Guided Psychotherapy for Children and Adolescents (FIRST): study protocol for a randomized controlled effectiveness trial in outpatient clinics
BackgroundHundreds of youth psychotherapy randomized trials have generated scores of helpful empirically supported treatments (ESTs). However, the...
-
Cervical collar use following anterior cervical hybrid surgery: protocol for a prospective randomized, time-controlled trial
IntroductionCervical hybrid surgery (HS) combines anterior cervical discectomy and fusion (ACDF) and cervical disc arthroplasty (CDA) to establish an...
-
Appropriate medication use in Dutch terminal care: study protocol of a multicentre stepped-wedge cluster randomized controlled trial (the AMUSE study)
BackgroundPolypharmacy is common among patients with a limited life expectancy, even shortly before death. This is partly inevitable, because these...
-
Reducing Violent Discipline by Teachers: a Matched Cluster-Randomized Controlled Trial in Tanzanian Public Primary Schools
Violent discipline in schools infringes on children’s rights and is associated with harmful developmental consequences for students. This calls for...
-
Ketamine for acute pain after trauma: the KAPT randomized controlled trial
BackgroundEvidence for effective pain management and opioid minimization of intravenous ketamine in elective surgery has been extrapolated to acutely...
-
The Impact of Restorative Practices on the Use of Out-of-School Suspensions: Results from a Cluster Randomized Controlled Trial
The overuse of exclusionary discipline practices, such as out-of-school suspensions (OSS), has consistently been documented over several decades. The...
