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In silico formulation of a next-generation multiepitope vaccine for use as a prophylactic candidate against Crimean-Congo hemorrhagic fever
BackgroundCrimean-Congo hemorrhagic fever (CCHF) is a widespread disease transmitted to humans and livestock animals through the bite of infected...
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Protective efficacy of multiepitope vaccines constructed from common antigens of Eimeria species in chickens
Clinical avian coccidiosis is typically caused by coinfection with several Eimeria species. Recombinant protein and DNA vaccines have shown promise...
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A multiepitope vaccine encoding four Eimeria epitopes with PLGA nanospheres: a novel vaccine candidate against coccidiosis in laying chickens
With a worldwide distribution, Eimeria spp. could result in serious economic losses to the poultry industry. Due to drug resistance and residues,...
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Design and evaluation of a multiepitope vaccine for pancreatic cancer using immune-dominant epitopes derived from the signature proteome in expression datasets
Pancreatic cancer is a highly aggressive and often lethal malignancy with limited treatment options. Its late-stage diagnosis and resistance to...
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Decoding bovine coronavirus immune targets: an epitope informatics approach
Bovine coronavirus (BCoV) poses a significant threat to the global cattle industry, causing both respiratory and gastrointestinal infections in...
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Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2
BackgroundCoronavirus disease 2019 (COVID-19) linked with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause severe illness and...
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Development of a novel multi‑epitope vaccine against the pathogenic human polyomavirus V6/7 using reverse vaccinology
BackgroundHuman polyomaviruses contribute to human oncogenesis through persistent infections, but currently there is no effective preventive measure...
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Designing multi-epitope-based vaccine targeting surface immunogenic protein of Streptococcus agalactiae using immunoinformatics to control mastitis in dairy cattle
BackgroundMilk provides energy as well as the basic nutrients required by the body. In particular, milk is beneficial for bone growth and development...
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Designing a novel multi-epitope vaccine to evoke a robust immune response against pathogenic multidrug-resistant Enterococcus faecium bacterium
Enterococcus faecium is an emerging ESKAPE bacterium that is capable of causing severe public health complications in humans. There are currently no...
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Human T-cell lymphotropic virus type 1 (HTLV-1) proposed vaccines: a systematic review of preclinical and clinical studies
BackgroundNumerous vaccination research experiments have been conducted on non-primate hosts to prevent or control HTLV-1 infection. Therefore,...
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Immunoinformatics approach for multi-epitope vaccine design against structural proteins and ORF1a polyprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
BackgroundThe lack of effective treatment against the highly infectious SARS-CoV-2 has aggravated the already catastrophic global health issue. Here,...
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A multiepitope peptide vaccine against HCV stimulates neutralizing humoral and persistent cellular responses in mice
BackgroundAlthough DAAs hold promise to significantly reduce rates of chronic HCV infections, its eradication still requires development of an...
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Antigen epitopes of animal coronaviruses: a mini-review
Coronaviruses are widespread in nature and can infect mammals and poultry, making them a public health concern. Globally, prevention and control of...
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Research progress on dendritic cell vaccines in cancer immunotherapy
Dendritic cell (DC) vaccines induce specific immune responses that can selectively eliminate target cells. In recent years, many studies have been...
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Dendritic cells as orchestrators of anticancer immunity and immunotherapy
Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells that regulate adaptive immunity, including against cancer....
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An evaluation of a recombinant multiepitope based antigen for detection of Toxoplasma gondii specific antibodies
BackgroundThe inefficiency of the current tachyzoite antigen-based serological assays for the serodiagnosis of Toxoplasma gondii infection mandates...
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Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence
Immunotherapies play critical roles in cancer treatment. However, given that only a few patients respond to immune checkpoint blockades and other...
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Dendritic cell biology and its role in tumor immunotherapy
As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor immunotherapy. Taking into account the many recent advances in...
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Bee Venom Immunotherapy: Current Status and Future Directions
Bee venom immunotherapy is the main treatment option for bee sting allergy. Its major limitations are the high percentage of allergic side effects...
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Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are...
