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Metabolome and microbiome multi-omics integration from a murine lung inflammation model of bronchopulmonary dysplasia
BackgroundRespiratory tract microbial dysbiosis can exacerbate inflammation and conversely inflammation may cause dysbiosis. Dysbiotic microbiome...
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Map** between headache specific and generic preference-based health-related quality of life measures
BackgroundThe Headache Impact Test (HIT-6) and the Chronic Headache Questionnaire (CH-QLQ) measure headache-related quality of life but are not...
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Sex differences in trigeminal neuralgia: a focus on radiological and clinical characteristics
BackgroundIt is well established that trigeminal neuralgia is more prevalent in females than in males. Neurovascular compression with morphological...
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The brain-first vs. body-first model of Parkinson’s disease with comparison to alternative models
The ultimate origin of Lewy body disorders, including Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB), is still incompletely understood....
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Validating the Delone and Mclean’s model in a develo** country’s infectious disease pandemic context.
BackgroundThis study aimed at validating the updated DeLone and McLean’s information systems success model (D&MISS) in a develo** country’s...
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Using PROMIS-29 to determine symptom burdens in the context of the Type 1 and 2 systemic lupus erythematosus (SLE) model: a cross sectional study
ObjectiveTo account for heterogeneity in systemic lupus erythematosus (SLE) and bridge discrepancies between patient- and physician-perceived SLE...
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A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model
BackgroundWnt/β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been...
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Efficiency determination of J-PET: first plastic scintillators-based PET scanner
BackgroundThe Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of...
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Computational biology and in vitro studies for anticipating cancer-related molecular targets of sweet wormwood (Artemisia annua)
BackgroundCancer is one of the leading causes of death worldwide. Recently, it was shown that many natural extracts have positive effects against...
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Hematopoietic stem cell transplantation-associated thrombotic microangiopathy and the role of advanced practice providers and pharmacists
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a severe and potentially life-threatening complication....
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Mechanistic model of radiotherapy-induced lung fibrosis using coupled 3D agent-based and Monte Carlo simulations
BackgroundMechanistic modelling of normal tissue toxicities is unfolding as an alternative to the phenomenological normal tissue complication...
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Potential mechanisms underlying the effect of hepatocyte growth factor on liver injury in short bowel syndrome model rats
PurposeThe purpose of this study was to investigate the autophagy associated with apoptosis in hepatic damage in the short bowel syndrome rat model.
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Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular...
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Immune-related lncRNAs pairs prognostic score model for prediction of survival in acute myeloid leukemia patients
Acute myeloid leukemia (AML) is one of the most common malignant and aggressive hematologic tumors, and risk stratification is indispensable to...
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Temporal Pitch Sensitivity in an Animal Model: Psychophysics and Scalp Recordings
Cochlear implant (CI) users show limited sensitivity to the temporal pitch conveyed by electric stimulation, contributing to impaired perception of...
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The synaptic hypothesis of schizophrenia version III: a master mechanism
The synaptic hypothesis of schizophrenia has been highly influential. However, new approaches mean there has been a step-change in the evidence...
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Primary Care for Veterans Experiencing Homelessness: a Narrative Review of the Homeless Patient Aligned Care Team (HPACT) Model
In 2011, the U.S. Department of Veterans Health (VA) implemented a homeless-tailored primary care medical home model called the Homeless Patient...
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Intimate partner violence and antenatal care utilization predictors in Uganda: an analysis applying Andersen’s behavioral model of healthcare utilization
BackgroundOptimal utilization of antenatal care (ANC) services improves positive pregnancy experiences and birth outcomes. However, paucity of...
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Establishing the Geriatric Emergency Department Intervention in Queensland emergency departments: a qualitative implementation study using the i-PARIHS model
BackgroundFrail older adults require specific, targeted care and expedited shared decision making in the emergency department (ED) to prevent poor...
