Search
Search Results
-
Navigation strategies in patients with vestibular loss tested in a virtual reality T-maze
During navigation, humans mainly rely on egocentric and allocentric spatial strategies, two different frames of reference working together to build a...
-
Neuroprotective effects of quinpirole on lithium chloride pilocarpine-induced epilepsy in rats and its underlying mechanisms
IntroductionEpilepsy is a common neurological disorder that presents with challenging mechanisms and treatment strategies. This study investigated...
-
Rapid ejaculator rats are more susceptible to anxiety compared with normal ejaculator rats
By observation of Sprague–Dawley male rats with different ejaculatory behaviors, we have identified distinct behavioral characteristics in rapid...
-
The effect of hippocampal NR2B-containing NMDA receptors on chronic cognitive dysfunction in rats with temporal lobe epilepsy
BackgroundWe have previously reported that hippocampal long-term potentiation (LTP) was suppressed in temporal lobe epilepsy (TLE) rats. The...
-
SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats
BackgroundAn increase in sirtuin 1 (SIRT1) reportedly attenuates early brain injury, delayed cerebral ischemia, and short-term neurologic deficits in...
-
Isoflurane-induced neuroinflammation and NKCC1/KCC2 dysregulation result in long-term cognitive disorder in neonatal mice
BackgroundThe inhalational anesthetic isoflurane is commonly utilized in clinical practice, particularly in the field of pediatric anesthesia....
-
Grain-sized moxibustion inhibits the progression of Alzheimer disease in 5XFAD transgenic mice
ObjectiveTo investigate whether grain-sized moxibustion at **nshu (BL15) and Shenshu (BL23) can alleviate cognitive decline and other pathologic...
-
The Insulin Sensitizer KBP-336 Prevents Diabetes-Induced Cognitive decline in ZDF Rats
Background and ObjectivesDiabetes and especially insulin resistance are associated with an increased risk of develo** cognitive dysfunction, making...
-
IGF-1’s protective effect on OSAS rats’ learning and memory
PurposePatients with obstructive sleep apnea syndrome (OSAS) frequently experience cognitive dysfunction, which may be connected to chronic...
-
Gao-Zi-Yao improves learning and memory function in old spontaneous hypertensive rats
AimsGao-Zi-Yao has long been a unique way for treating various diseases. The present study is to explore the effect of Gao-Zi-Yao on learning and...
-
Debris generated by laser and/or balloon cause cerebral infarction with different severity
The purpose of this study is to determine the effects that debris generated by laser and/or balloon on the brain. Debris generated by laser, balloon,...
-
Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer’s Disease male mice
Alzheimer’s Disease (AD) is a prevalent neurodegenerative disease characterized by tau hyperphosphorylation, Aβ1-42 aggregation and cognitive...
-
Effect of recurrent severe insulin-induced hypoglycemia on the cognitive function and brain oxidative status in the rats
BackgroundEpisodes of recurrent or severe hypoglycemia can occur in patients with diabetes mellitus, insulinoma, neonatal hypoglycemia, and...
-
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization
Depression is a common chronic psychiatric illness, which is resistant to medical treatments. While melatonin may alleviate certain depression...
-
Influence of white-light-emitting diodes on primary visual cortex layer 5 pyramidal neurons (V1L5PNs) and remodeling by blue-light-blocking lenses
Studies have explored the consequences of excessive exposure to white-light-emitting diodes (LEDs) in the retina. Hence, we aimed to assess the...
-
Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage
ObjectivePrevious research indicates a link between cognitive impairment and chronic kidney disease (CKD), but the underlying factors are not fully...
-
Evaluation of the behavioral, histopathological, and immunohistochemical effects resulting from ventriculosubcutaneous shunt obstruction in kaolin-induced hydrocephalus in rats
PurposeHydrocephalus is a brain disease prevalent in the pediatric population that presents complex pathophysiology and multiple etiologies. The best...
-
Age-related impairment of navigation and strategy in virtual star maze
BackgroundAlthough it is well known that aging impairs navigation performance, the underlying mechanisms remain largely unknown. Egocentric strategy...
-
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease
Cognitive deterioration and memory decline associated with the progression of Alzheimer’s disease (AD) primarily results from synaptic failure....
-
Electroacupuncture Alleviates Memory Deficits in APP/PS1 Mice by Targeting Serotonergic Neurons in Dorsal Raphe Nucleus
ObjectiveAlzheimer’s disease (AD) has become a significant global concern, but effective drugs able to slow down AD progression is still lacked....