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Molecular Profiling and Targeted Therapies in Gliomas
Purpose of ReviewMolecular profiling enables the evaluation of genetic alterations for the diagnosis and classification of gliomas and the selection...
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Novel epigenetic molecular therapies for imprinting disorders
Genomic imprinting disorders are caused by the disruption of genomic imprinting processes leading to a deficit or increase of an active allele. Their...
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Myasthenia gravis: the changing treatment landscape in the era of molecular therapies
Myasthenia gravis (MG) is an autoimmune disorder that affects the neuromuscular junction, leading to muscle weakness and fatigue. MG is caused by...
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Molecular mechanisms and emerging therapies in wild-type transthyretin amyloid cardiomyopathy
Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is an underrecognized cause of heart failure due to misfolded wild-type transthyretin...
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Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors
Purpose of ReviewThis review aims to provide a comprehensive overview of mesenchymal sinonasal tract tumors (STTs), a distinct subset of STTs....
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Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy
Recent advances in understanding the tumor’s biology in line with a constantly growing number of innovative technologies have prompted...
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Molecular mechanisms augmenting resistance to current therapies in clinics among cervical cancer patients
Cervical cancer (CC) is the fourth leading cause of cancer death (~ 324,000 deaths annually) among women internationally, with 85% of these deaths...
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Molecular matched targeted therapies for primary brain tumors—a single center retrospective analysis
PurposeMolecular diagnostics including next generation gene sequencing are increasingly used to determine options for individualized therapies in...
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Generation-Dependent Retention Rates and Reasons for Discontinuation of Molecular Targeted Therapies in Patients with Rheumatoid Arthritis: From FIRST Registry
IntroductionThe study aimed to optimize medical care for elderly patients with rheumatoid arthritis (RA) by examining the 3-year continuation rate...
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Financial toxicity and patient experience associated with financial burden of molecular-targeted and immune therapies for cancer: an observational study under public health insurance
BackgroundFinancial burden of cancer treatment can negatively affect patients and their families. This study aimed to evaluate the financial toxicity...
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Psoriasis and Molecular Target Therapies: Evidence of Efficacy in Preventing Cardiovascular Comorbidities
Psoriasis is now considered a systemic disease, and several comorbidities have been described such as cardiovascular diseases, neurologic and...
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Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is...
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Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
Neurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke,...
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Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS
Polycystic ovarian syndrome (PCOS) can cause infertility in females due to hyperandrogenism and neuroendocrine abnormalities. The aim of this study...
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The role of HER2 alterations in clinicopathological and molecular characteristics of breast cancer and HER2-targeted therapies: a comprehensive review
Breast cancer (BC) is the most common malignancy in women and one of the leading causes of cancer mortality, despite significant treatment...
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Alzheimer’s Disease: Combination Therapies and Clinical Trials for Combination Therapy Development
Alzheimer’s disease (AD) is a complex multifaceted disease. Recently approved anti-amyloid monoclonal antibodies slow disease progression by...
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Cutaneous vasculitis associated with molecular tergeted therapies: systematic review of the literature
Cutaneo us vasculitis (CV) has a broad spectrum of etiologies, and drugs are one of the main culprits. With the increasing use of targeted therapies...
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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)
There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and...
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New Molecular Insights, and the Role of Systemic Therapies and Collaboration for Treatment of Epithelioid Hemangioendothelioma (EHE)
Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated vascular sarcoma. EHE can have different clinical presentations from indolent...
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Facioscapulohumeral muscular dystrophy: the road to targeted therapies
Advances in the molecular understanding of facioscapulohumeral muscular dystrophy (FSHD) have revealed that FSHD results from epigenetic...
