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Potential molecular targets and drugs for basement membranes-related intervertebral disk degeneration through bioinformatics analysis and molecular docking
BackgroundThrough bioinformatics analysis to identify the hub genes of Intervertebral disc degeneration (IVDD) associated with basement membranes...
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Parathyroid carcinoma: molecular therapeutic targets
Parathyroid carcinoma (PC) is an extremely rare malignant tumor of the parathyroid glands, accounting for less than 1% of primary...
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Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics
Psychedelics, also known as classical hallucinogens, have been investigated for decades due to their potential therapeutic effects in the treatment...
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Integrated investigation and discovery of therapeutic targets for 3-hydroxybakuchiol against diabetes based on molecular docking studies and cell experiments
BackgroundDiabetes mellitus is a prevalent endocrine condition. We aimed to investigate the anti-diabetic effects of 3-hydroxybakuchiol (HYD) by...
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Integrating network pharmacology, bioinformatics, and experimental validation to unveil the molecular targets and mechanisms of galangin for treating hepatocellular carcinoma
BackgroundGalangin, a flavonoid compound, is derived from Alpinia officinarum Hance. Previous studies have shown that galangin can inhibit the...
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Nd-Mn Molecular Cluster with Searched Targets for Oral Cancer Imaging
In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC)...
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Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages...
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Unraveling the complexity of the molecular pathways associated with polycystic ovary syndrome (PCOS) and identifying molecular targets for therapeutic development: a review of literature
BackgroundPolycystic ovary syndrome (PCOS) is the most typical endocrine disorder affecting women worldwide. Although the etiology of PCOS is not...
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Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The protein quality control...
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Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite...
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Identification and validation of targets of swertiamarin on idiopathic pulmonary fibrosis through bioinformatics and molecular docking-based approach
BackgroundSwertiamarin is the main hepatoprotective component of Swertiapatens and has anti-inflammatory and antioxidation effects. Our previous...
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Computational biology and in vitro studies for anticipating cancer-related molecular targets of sweet wormwood (Artemisia annua)
BackgroundCancer is one of the leading causes of death worldwide. Recently, it was shown that many natural extracts have positive effects against...
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RAS and Other Molecular Targets in Pancreatic Cancer: The Next Wave Is Coming
Since the discovery of oncogenes in the 1970s, cancer doctors and researchers alike have understood the promise of discovering drugs to block the...
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Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study
BackgroundArdisia gigantifolia Stapf. (AGS), a Chinese folk medicine widely grows in the south of China and several studies reported that AGS could...
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Novel Biomarkers and Molecular Targets in ALL
Purpose of ReviewAcute lymphoblastic leukemia (ALL) is a widely heterogeneous disease in terms of genomic alterations, treatment options, and...
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Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited...
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Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the conversion from mechanical signals to biochemical signals...
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Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones
The pharmacological effects of natural product therapy have received sigificant attention, among which terpenoids such as sesquiterpene lactones...
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Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of macronutrient (lipid, carbohydrate, protein) metabolism...
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Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin...
