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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)
There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and...
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Molecular-targeted therapy for childhood low-grade glial and glioneuronal tumors
Since the discovery of the association between BRAF mutations and fusions in the development of childhood low-grade gliomas and the subsequent...
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Targeted Therapy for MPNs: Going Beyond JAK Inhibitors
Purpose of ReviewJAK inhibition is an effective means of controlling symptom burden and improving splenomegaly in patients with myeloproliferative...
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Molecular Profiling and Targeted Therapies in Gliomas
Purpose of ReviewMolecular profiling enables the evaluation of genetic alterations for the diagnosis and classification of gliomas and the selection...
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Targeted Systemic Therapies for Adults with Atopic Dermatitis: Selecting from Biologics and JAK Inhibitors
Therapeutic options for people with moderate or severe atopic dermatitis refractory to topical therapy have rapidly expanded in recent years. These...
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Molecular docking and MD simulation studies of 4-thiazol-N-(pyridin-2-yl)pyrimidin-2-amine derivatives as novel inhibitors targeted to CDK2/4/6
PurposeNowadays, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have been approved for treating metastatic breast cancer and have achieved inspiring...
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Generation-Dependent Retention Rates and Reasons for Discontinuation of Molecular Targeted Therapies in Patients with Rheumatoid Arthritis: From FIRST Registry
IntroductionThe study aimed to optimize medical care for elderly patients with rheumatoid arthritis (RA) by examining the 3-year continuation rate...
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Advances in the molecular mechanism and targeted therapy of radioactive-iodine refractory differentiated thyroid cancer
Most patients with differentiated thyroid cancer have a good prognosis after radioactive iodine-131 treatment, but there are still a small number of...
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Molecular and functional imaging in cancer-targeted therapy: current applications and future directions
Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor growth rather...
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Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy
Recent advances in understanding the tumor’s biology in line with a constantly growing number of innovative technologies have prompted...
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Effective combination treatments for breast cancer inhibition by FOXM1 inhibitors with other targeted cancer drugs
PurposeFew targeted treatment options currently exist for patients with advanced, often recurrent breast cancers, both triple-negative breast cancer...
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Molecular perspective on targeted therapy in breast cancer: a review of current status
Breast cancer is categorized at the molecular level according to the status of certain hormone and growth factor receptors, and this classification...
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Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors
Purpose of ReviewThis review aims to provide a comprehensive overview of mesenchymal sinonasal tract tumors (STTs), a distinct subset of STTs....
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Liquid biopsy guides successful molecular targeted therapy of an inoperable pediatric brainstem neoplasm
Midline CNS tumors are occasionally inaccessible for surgical biopsies. In these instances, cell-free DNA (cfDNA) may serve as a viable alternative...
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Molecular matched targeted therapies for primary brain tumors—a single center retrospective analysis
PurposeMolecular diagnostics including next generation gene sequencing are increasingly used to determine options for individualized therapies in...
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Recent advances in the molecular targeted drugs for prostate cancer
ContextProstate cancer (PCa) is the second largest male tumor in the world and one of the most common malignant tumors in the urinary system. In...
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Financial toxicity and patient experience associated with financial burden of molecular-targeted and immune therapies for cancer: an observational study under public health insurance
BackgroundFinancial burden of cancer treatment can negatively affect patients and their families. This study aimed to evaluate the financial toxicity...
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Targeted molecular profiling of solid tumours-Indian tertiary cancer centre experience
PurposeMolecular Profiling of solid tumours is extensively used for prognostic, theranostic, and risk prediction. Next generation sequencing (NGS)...
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Molecular targeted drugs resistance impairs double-strand break repair and sensitizes ER-positive breast cancer to PARP inhibitors
BackgroundThere are various treatments for estrogen-positive breast cancer, mainly hormone therapy and molecular-targeted drugs. Acquiring resistance...
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Place in Therapy of Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer: A Targeted Literature Review
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) are the preferred regimen for patients with hormone receptor-positive and human epidermal growth...
