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Clinical spreading of muscle weakness in amyotrophic lateral sclerosis (ALS): a study in 910 patients
BackgroundNeuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS) indicates that neurodegeneration may spread corticofugally.
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From spreading depolarization to blood–brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy
Considerable strides in medical interventions during the acute phase of traumatic brain injury (TBI) have brought improved overall survival rates....
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MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as...
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Mechanisms of initiation of cortical spreading depression
BackgroundThere is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiological correlate of...
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Impact of Human Activities on Disease-Spreading Mosquitoes in Urban Areas
AbstractUrbanization is one of the leading global trends of the twenty-first century that has a significant impact on health. Among health challenges...
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Estrogen modulation of cortical spreading depression
Background and aimsCortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral...
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Brain regions susceptible to alpha-synuclein spreading
The spreading of misfolded alpha-synuclein (α-syn) protein has been observed in animal models of Parkinson’s disease (PD) and other...
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The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention
BackgroundWhen a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no...
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Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization
BackgroundWithin 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain....
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Microglia Modulate Cortical Spreading Depolarizations After Ischemic Stroke: A Narrative Review
Cortical spreading depolarizations (CSDs) are characterized by waves of diminished electroencephalography activity that propagate across the cortex...
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Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization
An acute reduction in plasma osmolality causes rapid uptake of water by astrocytes but not by neurons, whereas both cell types swell as a consequence...
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Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form...
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Cerebrovascular Pressure Reactivity According to Long-Pressure Reactivity Index During Spreading Depolarizations in Aneurysmal Subarachnoid Hemorrhage
BackgroundSpreading depolarization (SD) has been linked to the impairment of neurovascular coupling. However, the association between SD occurrence...
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Spreading Activity in Bovine Udder Extract
Spreading activity for bovine udder extract has been demonstrated by the intradermal injection of the extract together with Evan’s blue into rabbit...
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Integrated Analysis Identifies Novel Fusion Transcripts in Laterally Spreading Tumors Suggestive of Distinct Etiology Than Colorectal Cancers
BackgroundLaterally spreading tumors (LSTs) of the colon and rectum are a class of abnormality which spreads laterally and appears ulcerated. They...
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Recurrences of advanced sessile and lateral spreading colorectal adenoma after endoscopic mucosal resection (EMR) thermal ablation versus no adjuvant therapy (RESPECT): a protocol of an international randomized controlled trial
BackgroundNowadays, large benign lateral spreading lesions (LSLs) and sessile polyps in the colorectum are mostly resected by endoscopic mucosal...
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Evolution of superficial spreading melanoma to resemble desmoplastic melanoma: case report
Desmoplastic melanoma commonly occurs on the head and neck in a pure form, but occasionally, it occurs in a mixed tumor with another type, usually...
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Cortical Anoxic Spreading Depolarization During Cardiac Arrest is Associated with Remote Effects on Peripheral Blood Pressure and Postresuscitation Neurological Outcome
BackgroundSpreading depolarizations (SDs) are self-propagating waves of neuronal and glial depolarizations often seen in neurological conditions in...
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Cortical Spreading Depolarization, Blood Flow, and Cognitive Outcomes in a Closed Head Injury Mouse Model of Traumatic Brain Injury
BackgroundCortical spreading depolarizations (CSDs) are associated with worse outcomes in many forms of acute brain injury, including traumatic brain...
