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Molecular Profiling and Targeted Therapies in Gliomas
Purpose of ReviewMolecular profiling enables the evaluation of genetic alterations for the diagnosis and classification of gliomas and the selection...
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Molecular profiling of the hippocampus of children with autism spectrum disorder
Several lines of evidence point to a key role of the hippocampus in Autism Spectrum Disorders (ASD). Altered hippocampal volume and deficits in...
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Recent advances in molecular profiling of bone and soft tissue tumors
The molecular characterization of soft tissue and bone tumors is a rapidly evolving field that has changed the perspective of how these tumors are...
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DNA methylation profiling of meningiomas highlights clinically distinct molecular subgroups
BackgroundIntroduction of the classification of brain tumours based on DNA methylation profile has significantly changed the diagnostic approach. Due...
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Molecular profiling in lung cancer
The biology of non-small cell lung cancer (NSCLC) is driven by a complex mutational landscape, and the detection of driver molecular alterations by...
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Supporting the decision to perform molecular profiling for cancer patients based on routinely collected data through the use of machine learning
BackgroundPersonalized medicine offers targeted therapy options for cancer treatment. However, the decision whether to include a patient into...
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Targeted molecular profiling of solid tumours-Indian tertiary cancer centre experience
PurposeMolecular Profiling of solid tumours is extensively used for prognostic, theranostic, and risk prediction. Next generation sequencing (NGS)...
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Metamorphosis of Dentigerous cyst: A case Series with Insight into Molecular Profiling
The objective of this study was to review the clinical, radiologic, and histologic aspects of cases of dentigerous cysts metamorphosing into...
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Therapeutic yield of extensive molecular profiling in cholangiocarcinoma: a retrospective single-center study
IntroductionCurrent available systemic therapies for advanced cholangiocarcinoma (CCA) are of limited effectiveness and prognosis is poor. Recently,...
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The practical utility of AI-assisted molecular profiling in the diagnosis and management of cancer of unknown primary: an updated review
Cancer of unknown primary (CUP) presents a complex diagnostic challenge, characterized by metastatic tumors of unknown tissue origin and a dismal...
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Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body and tail
Pancreatic ductal adenocarcinoma (PDAC) of the head (H) and body/tail (B/T) differ in embryonic origin, cell composition, blood supply, lymphatic and...
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Molecular profiling of biliary tract cancers reveals distinct genomic landscapes between circulating and tissue tumor DNA
Biliary tract cancers (BTCs) are heterogeneous malignancies with dismal prognosis due to tumor aggressiveness and poor response to limited current...
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Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, occurring predominantly in patients with underlying...
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Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms
Knowledge on the pathogenesis of FL is mainly based on data derived from advanced/systemic stages of FL (sFL) and only small cohorts of localized FL...
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Integrating Functional Imaging and Molecular Profiling for Optimal Treatment Selection in Neuroendocrine Neoplasms (NEN)
Purpose of ReviewGastroenteropancreatic NEN (GEP-NEN) are group of malignancies with significant clinical, anatomical and molecular heterogeneity....
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The Molecular Landscape of Gastric Cancers for Novel Targeted Therapies from Real-World Genomic Profiling
BackgroundPanel-based comprehensive genomic profiling is used in clinical practice worldwide; however, large real-world datasets of patients with...
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Molecular profiling and prognostic analysis in Chinese cholangiocarcinoma: an observational, retrospective single-center study
Cholangiocarcinoma (CCA) is a primary malignancy which is often diagnosed when it is advanced and inoperable due to the lack of effective biomarkers...
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Tumor Molecular Profiling in Hispanics: Moving Towards Precision Oncology and Health Equity
BackgroundTumor molecular profiling techniques, such as next-generation sequencing (NGS) to identify somatic genetic alterations, allow physicians to...
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Molecular profiling leading to personalized treatment in breast cancer
With the development of various targeted therapies in breast cancer, detection of biomarkers for predicting treatment efficacy gains importance. With...
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Molecular profiling of EBV associated diffuse large B-cell lymphoma
Epstein-Barr virus (EBV) associated diffuse large B-cell lymphoma (DLBCL) represents a rare aggressive B-cell lymphoma subtype characterized by an...
