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Combined Hepatic Arterial Infusion Pump and Systemic Chemotherapy in the Modern Era for Chemotherapy-Naive Patients with Unresectable Colorectal Liver Metastases
PurposeChemotherapy-naive patients with unresectable colorectal liver metastases (CRLM) have been the best responders to hepatic arterial infusion...
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The oligometastatic spectrum in the era of improved detection and modern systemic therapy
Metastases remain the leading cause of cancer-related mortality. The oligometastasis hypothesis postulates that a spectrum of metastatic spread...
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Survival outcomes of lung metastases from colorectal cancer treated with pulmonary metastasectomy or modern systemic chemotherapy: a single institution experience
BackgroundAlthough pulmonary metastasectomy is an accepted treatment strategy for resectable lung metastases (LM) from colorectal cancer (CRC), its...
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Current treatment of systemic lupus erythematosus: a clinician's perspective
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Its variable course makes it difficult to standardize patient treatment. This...
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The neurovascular unit and systemic biology in stroke — implications for translation and treatment
Ischaemic stroke is a leading cause of disability and death for which no acute treatments exist beyond recanalization. The development of novel...
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Perceived treatment satisfaction in patients with systemic rheumatic diseases treated with biologic therapies: results of a self-reported survey
Biological agents are widely used for the management of systemic rheumatic diseases (SRDs) and their therapeutic implications have been expanded...
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Metabolomics in systemic sclerosis
Systemic sclerosis is a rare autoimmune condition leading to incurable complications. Therefore fast and precise diagnosis is crucial to prevent...
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Can multi-modal radiomics using pretreatment ultrasound and tomosynthesis predict response to neoadjuvant systemic treatment in breast cancer?
ObjectivesResponse assessment to neoadjuvant systemic treatment (NAST) to guide individualized treatment in breast cancer is a clinical research...
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Survival Outcomes of Salvage Metastasectomy After Failure of Modern-Era Systemic Therapy for Melanoma
BackgroundMetastasectomy for selected patients with melanoma was associated with improved survival in the era before effective systemic therapy....
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Modern view on the diagnostics and treatment of adenomyosis
Adenomyosis is identified by the enlargement of the uterus secondary to such areas of the endometrium as the endometrial glands and stroma located...
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Immunotherapy Versus Hospice: Treatment Decision-Making in the Modern Era of Novel Cancer Therapies
Purpose of ReviewModern advances in cancer treatment with immunotherapy have created substantial hope for patients and oncologists alike due to a new...
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Neuro-ophthalmic complications of modern anti-cancer drugs
PurposeTargeted cancer therapies have been responsible for a dramatic shift in treatment strategies for cancer, and the number of drugs, classes, and...
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Integrating Multidisciplinary Treatment for Advanced Renal Cell Carcinoma
The field of kidney cancer has dramatically evolved over the past several years due to notable advances. Most importantly, systemic treatment options...
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Brain metastases: new systemic treatment approaches
BackgroundBrain metastases (BM) still present a clinical challenge in oncology. Treatment of BM was mainly based on local approaches including...
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The Development of Modern Radiation Therapy
Purpose of ReviewRadiation therapy is a treatment modality used in the management of patients with cancer that utilizes ionizing radiation to kill...
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Prophylactic strategies for hand-foot syndrome/skin reaction associated with systemic cancer treatment: a meta-analysis of randomized controlled trials
PurposeHand-foot syndrome (HFS) and hand-foot skin reaction (HFSR) are common toxicities of several systemic cancer treatments. Multikinase...
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Avapritinib in the Treatment of Systemic Mastocytosis: an Update
Purpose of ReviewPatients with systemic mastocytosis, a dangerous and rare myeloid neoplasm, have long had few therapies available to them and,...
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Precision medicine in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease that has diverse clinical manifestations, ranging from restricted cutaneous involvement...
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The therapeutic potential of immunoengineering for systemic autoimmunity
Disease-modifying drugs have transformed the treatment options for many systemic autoimmune diseases. However, an evolving understanding of disease...
