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Cardiac Involvement in Mitochondrial Disorders
Purpose of ReviewWe review pathophysiology and clinical features of mitochondrial disorders manifesting with cardiomyopathy.
Recent Findings ...
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Mitochondrial disorders as a mechanism for the development of obese Sarcopenia
Obese sarcopenia is a severe and prevalent disease in an aging society. Compared to sarcopenia alone, the development and advanced stage of obesity...
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Current management of primary mitochondrial disorders in EU countries: the European Reference Networks survey
Background and purposePrimary mitochondrial diseases (PMDs) are rare diseases for which diagnosis is challenging, and management and training...
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Sleep Disorders in Mitochondrial Diseases
Purpose of ReviewWe aim to summarize the sleep disorders reported in patients affected by primary mitochondrial dysfunctions and describe the...
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ENT characteristics and therapeutic results in multisystemic disorders of mitochondrial encephalomyopathy
Here we report the evaluation of the frequency of subjective and objective otolaryngologic findings and therapeutic results in 32 patients with...
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Mitochondrial modulators for obsessive–compulsive and related disorders: a systematic review and meta-analysis
It remains unclear whether mitochondrial modulators (MMs) are beneficial in the treatment of obsessive–compulsive and related disorders. Thus, in an...
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Genetics of Mitochondrial Cardiomyopathy
Purpose of ReviewPrimary mitochondrial disorders (PMD) are a heterogeneous group of individual genetic multi-systemic diseases that are challenging...
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Mitochondrial epigenetic modifications and nuclear-mitochondrial communication: A new dimension towards understanding and attenuating the pathogenesis in women with PCOS
Mitochondrial DNA (mtDNA) epigenetic modifications have recently gained attention in a plethora of complex diseases, including polycystic ovary...
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Mitochondrial Replacement Therapy: An Islamic Perspective
Mitochondrial replacement technology (MRT) is an emerging and complex bioethical issue. This treatment aims to eliminate maternal inherited...
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Mitochondrial health index correlates with plasma circulating cell-free mitochondrial DNA in bipolar disorder
Although mitochondrial dysfunction is known to play an essential role in the pathophysiology of bipolar disorder (BD), there is a glaring gap in our...
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Mitochondrial dynamics in health and disease: mechanisms and potential targets
Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity...
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Adult-onset mitochondrial movement disorders: a national picture from the Italian Network
IntroductionBoth prevalence and clinical features of the various movement disorders in adults with primary mitochondrial diseases are unknown.
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Mitochondrial Dysfunction in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a multi-causal condition. Among the genetic causes, variations in the mitochondrial DNA (mtDNA) are increasingly...
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Mitochondrial dysfunction: mechanisms and advances in therapy
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression....
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The Ketogenic Diet as a Treatment for Mood Disorders
Purpose of ReviewThe ketogenic diet is a low carbohydrate, moderate protein, and high fat diet which results in a metabolic state known as ketosis,...
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The potential of baicalin to enhance neuroprotection and mitochondrial function in a human neuronal cell model
Baicalin is a flavone glycoside derived from flowering plants belonging to the Scutellaria genus. Previous studies have reported baicalin’s...
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Wide diagnostic and genotypic spectrum in patients with suspected mitochondrial disease
BackgroundMitochondrial Diseases (MDs) are a diverse group of neurometabolic disorders characterized by impaired mitochondrial oxidative...
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Mitochondrial function and gastrointestinal diseases
Mitochondria are dynamic organelles that function in cellular energy metabolism, intracellular and extracellular signalling, cellular fate and stress...
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SETD5 haploinsufficiency affects mitochondrial compartment in neural cells
BackgroundNeurodevelopmental disorders (NDDs) are heterogeneous conditions due to alterations of a variety of molecular mechanisms and cell...
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Mitochondrial homeostasis: sha** health and disease
Mitochondria serve as the primary site for metabolizing the three major nutrients, underscoring their pivotal role in cellular energy metabolism and...
