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Phenoty** of cancer-associated somatic mutations in the BCL2 transmembrane domain
The BCL2 family of proteins controls cell death by modulating the permeabilization of the mitochondrial outer membrane through a fine-tuned...
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Transmembrane protein 117 knockdown protects against angiotensin-II-induced cardiac hypertrophy
Mitochondrial dysfunction plays a critical role in the pathogenesis of pathological cardiac hypertrophy. Transmembrane protein 117 modulate...
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Mitochondrial dynamics in health and disease: mechanisms and potential targets
Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity...
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Depolarized Mitochondrial Membrane Potential and Elevated Calcium in Platelets of Sickle Cell Disease
Hemolysis, a crucial feature of Sickle cell disease (SCD), is a key player for cellular activation leading to various complications including...
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Mitochondrial dysfunction: mechanisms and advances in therapy
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression....
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Machine learning and single-cell sequencing reveal the potential regulatory factors of mitochondrial autophagy in the progression of gastric cancer
BackgroundAs an important regulatory mechanism to remove damaged mitochondria and maintain the balance between internal and external cells,...
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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a ‘highly transmissible respiratory pathogen, leading to severe multi-organ damage....
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Mitochondrial quality control in human health and disease
Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their...
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Mitochondrial homeostasis: sha** health and disease
Mitochondria serve as the primary site for metabolizing the three major nutrients, underscoring their pivotal role in cellular energy metabolism and...
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Mitochondrial function and gastrointestinal diseases
Mitochondria are dynamic organelles that function in cellular energy metabolism, intracellular and extracellular signalling, cellular fate and stress...
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Targeting mitochondrial shape: at the heart of cardioprotection
There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute...
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Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
Regulation of RNA stability and translation by RNA-binding proteins (RBPs) is a crucial process altering gene expression. Musashi family of RBPs...
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Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium (Ca 2+ ) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitochondrial Ca 2+ levels modulate...
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Progress of Mitochondrial Function Regulation in Cardiac Regeneration
Heart failure and myocardial infarction, global health concerns, stem from limited cardiac regeneration post-injury. Myocardial infarction, typically...
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Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose
CD19 CAR-T cells have led to durable remissions in patients with refractory B-cell malignancies; nevertheless, most patients eventually relapse in...
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Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine
BackgroundMigraine, a complex brain disorder, is regarded as a possible clinical manifestation of brain energy dysfunction. The trigeminovascular...
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Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis
Acute lung injury (ALI) is one of the life-threatening complications of sepsis, and macrophage polarization plays a crucial role in the...
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DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth
Transient early endosome (EE)-mitochondria interactions can mediate mitochondrial iron translocation, but the associated mechanisms are still...
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Mitochondrial DNA is a key driver in cigarette smoke extract-induced IL-6 expression
Smoking is an independent risk factor for atherosclerosis, the primary pathogenesis of which is inflammation. We recently reported that cigarette...
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Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds
Purpose of ReviewThe global obesity epidemic has become a major public health concern, necessitating comprehensive research into its adverse effects...
