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Mitochondrial health index correlates with plasma circulating cell-free mitochondrial DNA in bipolar disorder
Although mitochondrial dysfunction is known to play an essential role in the pathophysiology of bipolar disorder (BD), there is a glaring gap in our...
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Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder
Bipolar disorder (BD) is a global medical issue, afflicting around 1% of the population with manic and depressive episodes. Despite various genetic...
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Auditory Brainstem Response in a Child with Mitochondrial Disorder–Leigh Syndrome
The mitochondrial disorder–Leigh syndrome is a neurodegenerative disorder often manifested with brainstem abnormalities. The case report highlights...
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Expanded clinical phenotype and untargeted metabolomics analysis in RARS2-related mitochondrial disorder: a case report
BackgroundRARS2 -related mitochondrial disorder is an autosomal recessive mitochondrial encephalopathy caused by biallelic pathogenic variants in the...
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Mitochondrial genetic variants associated with bipolar disorder and Schizophrenia in a Japanese population
BackgroundBipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including...
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Systematic review of mitochondrial genetic variation in attention-deficit/hyperactivity disorder
The global prevalence of attention-deficit/hyperactivity disorder (ADHD) is estimated to be between 6% and 7% in children worldwide. The...
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Pilot study of circulating cell-free mitochondrial DNA in relation to brain structure in youth bipolar disorder
BackgroundMitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Higher circulating cell-free mitochondrial DNA...
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Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder
We compared transcriptomic profiles of cerebral organoids differentiated from induced pluripotent stem cells of eight schizophrenia and eight bipolar...
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Nuclear Mitochondrial Disorder Due to a Variant in NAXE in Two Unrelated Indian Children
Progressive encephalopathy with brain edema and/or leukoencephalopathy type 1 (PEBEL1) is a nuclear mitochondrial disorder involving the NAD(P)HX...
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Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is associated with unique changes in mitochondrial metabolism, including...
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Metabolic features of treatment-refractory major depressive disorder with suicidal ideation
Peripheral blood metabolomics was used to gain chemical insight into the biology of treatment-refractory Major Depressive Disorder with suicidal...
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Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder
To characterize neuronal mitochondrial abnormalities in major depressive disorder (MDD), functional mitochondrial proteins (MPs) extracted from...
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Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?
Recent studies have suggested that mitochondrial dysfunction and dysregulated neuroinflammatory pathways are involved in the pathophysiology of major...
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Mitochondrial epigenetic modifications and nuclear-mitochondrial communication: A new dimension towards understanding and attenuating the pathogenesis in women with PCOS
Mitochondrial DNA (mtDNA) epigenetic modifications have recently gained attention in a plethora of complex diseases, including polycystic ovary...
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Mitochondrial, cell cycle control and neuritogenesis alterations in an iPSC-based neurodevelopmental model for schizophrenia
Schizophrenia is a severe psychiatric disorder of neurodevelopmental origin that affects around 1% of the world’s population. Proteomic studies and...
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Mitochondrial dysfunction: mechanisms and advances in therapy
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression....
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Mitochondrial Dysfunction in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a multi-causal condition. Among the genetic causes, variations in the mitochondrial DNA (mtDNA) are increasingly...
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Genetics of Mitochondrial Cardiomyopathy
Purpose of ReviewPrimary mitochondrial disorders (PMD) are a heterogeneous group of individual genetic multi-systemic diseases that are challenging...
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Telomere length and mitochondrial DNA copy number in bipolar disorder: identification of a subgroup of young individuals with accelerated cellular aging
The 10–15-years decrease in life expectancy observed in individuals with bipolar disorder (BD) has been linked to the concept of accelerated cellular...
