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Oral midazolam vs. intranasal dexmedetomidine plus oral midazolam for sedation of pediatric outpatients: a double-blinded randomized controlled trial
BackgroundModerate to deep sedation is required for dental treatment of children with dental anxiety. Midazolam is the most commonly used sedative,...
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Treatment of agitation in terminally ill patients with intranasal midazolam versus subcutaneous midazolam: study protocol for a randomised controlled open-label monocentric trial (MinTU Study)
BackgroundIntranasal (i.n.) drug application is a widely known and low-invasive route of administration that may be able to achieve rapid symptom...
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Levetiracetam and Midazolam vs Midazolam Alone for First-Line Treatment of Children With Generalized Convulsive Status Epilepticus (Lev-Mid Study): A Randomized Controlled Trial
BackgroundBenzodiazepines are the first-line anti-seizure medication (ASM) for generalized convulsive status epilepticus (GCSE), but they fail to end...
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Grading the level of evidence of neonatal pharmacotherapy: midazolam and phenobarbital as examples
BackgroundMany drugs are used off-label or unlicensed in neonates. This does not mean they are used without evidence or knowledge. We aimed to apply...
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Residual unabsorbed midazolam: a case report
BackgroundOral midazolam is commonly administered to reduce anxiety in children presenting for medical procedures or surgery. It is unclear what...
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Pharmacokinetic study of capivasertib and the CYP3A4 substrate midazolam in patients with advanced solid tumors
PurposeCapivasertib, a potent, selective inhibitor of all three AKT serine/threonine kinase (AKT) isoforms, is being evaluated in phase 3 trials in...
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Predictors of pediatric sedation failure with initial dose of intranasal dexmedetomidine and oral midazolam
BackgroundTo assess the sedative failure rate over different dose combinations of intranasal dexmedetomidine and oral midazolam for procedural...
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A Comparison of Ketamine and Midazolam as First-Line Anesthetic Infusions for Pediatric Status Epilepticus
BackgroundPediatric refractory status epilepticus (RSE) often requires management with anesthetic infusions, but few data compare first-line...
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Intraindividual Variability in Absolute Bioavailability and Clearance of Midazolam in Healthy Individuals
Background and ObjectiveMidazolam is the preferred clinical probe drug for assessing CYP3A activity. We have previously shown substantial...
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Safety, Pharmacokinetics, and Pharmacodynamics of Midazolam Gel After Rectal Administration in Healthy Chinese Subjects
Background and ObjectivesMidazolam rectal gel is a novel rectal formulation that may be a promising and potential alternative to oral administration...
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An evaluation of dexmedetomidine in combination with midazolam in pediatric sedation: a systematic review and meta-analysis
BackgroundDexmedetomidine and midazolam are commonly used sedatives in children. We conducted a systematic review and meta-analysis to compare the...
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Alcohol spiked with zolpidem and midazolam potentiates inflammation, oxidative stress and organ damage in a mouse model
PurposeCrime-related spiking of alcoholic drinks with prescription drugs is quite common and has been happening for centuries. This study, therefore,...
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Comparative analysis of dexmedetomidine, midazolam, and propofol impact on epilepsy-related mortality in the ICU: insights from the MIMIC-IV database
BackgroundDexmedetomidine (Dex), midazolam, and propofol are three distinct sedatives characterized by varying pharmacological properties. Previous...
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Effect of Daridorexant on the Pharmacokinetics of Midazolam, and on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Male Subjects
Background and ObjectivesDaridorexant, a dual orexin receptor antagonist was recently approved for the treatment of insomnia at doses up to 50 mg...
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Combined sedation in pediatric magnetic resonance imaging: determination of median effective dose of intranasal dexmedetomidine combined with oral midazolam
BackgroundThe exact median effective dose (ED50) of intranasal dexmedetomidine combined with oral midazolam sedation for magnetic resonance imaging...
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The effect of age on outpatient pediatric procedural sedation with intranasal dexmedetomidine and oral midazolam
AbstractProcedural sedation for diagnostic examination is a common practice in children. The study aims to analyze the sedative effect and safety of...
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Intranasal midazolam alone versus midazolam/ketamine combination for preoperative sedation in pediatric patients undergoing ophthalmic procedures: a randomized controlled trial
BackgroundInteraction with medical providers is a stressful experience for a child. The current study aimed to assess the efficacy and safety of...
