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Detection of myeloma cell-derived microvesicles: a tool to monitor multiple myeloma load
The persistence of tumor load in multiple myeloma (MM) lead to relapse in patients achieving complete remission (CR). Appropriate and effective...
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Effect of human bone marrow mesenchymal stem cell-derived microvesicles on the apoptosis of the multiple myeloma cell line U266
BackgroundMicrovesicles are membraned particles produced by different types of cells recently investigated for anticancer purposes. The current study...
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Platelet-derived microvesicles (PMVs) in cancer progression and clinical applications
Platelet-derived microvesicles (PMVs), the microvesicles with the highest concentration in the bloodstream, play a key role in the regulation of...
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Circulating microvesicles across a population with various degree of cardiovascular burden are associated with systolic blood pressure
Circulating microvesicles (MVs) have been studied in heterogeneous, divergent, and rather small patient populations with cardiovascular risk ....
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Leukemogenesis occurs in a microenvironment enriched by extracellular microvesicles/exosomes: recent discoveries and questions to be answered
In single-cell organisms, extracellular microvesicles (ExMVs) were one of the first cell-cell communication platforms that emerged very early during...
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Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles
BackgroundVascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon sepsis. We hypothesized that...
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Development and nationwide validation of kidney graft injury markers using urinary exosomes and microvesicles (complete English translation of the Japanese version)
BackgroundNon-invasive, prompt, and proper detection tools for kidney graft injuries (KGIs) are awaited to ensure graft longevity. We screened...
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Assessment of microvesicles from different cell origins in patients with psoriasis: evidence of thrombogenic, proinflammatory microenvironment in the absence of established cardiovascular disease
Psoriasis is associated with increased cardiovascular risk. Endothelial, platelet, and erythrocyte microvesicles (MVs) are novel biomarkers of...
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A study of endothelial and platelet microvesicles across different hypertension phenotypes
Rather than being mere biomarkers reflecting generalized vascular injury, endothelial- (EMVs) and platelet-derived (PMVs) microvesicles have emerged...
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Pentraxin 3 in Circulating Microvesicles: a Potential Biomarker for Acute Heart Failure After Cardiac Surgery with Cardiopulmonary Bypass
The aim of this study was to investigate whether pentraxin 3 (PTX3) in microvesicles (MVs) can be a valuable biomarker for the prediction of acute...
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Isolation and characterization of urine microvesicles from prostate cancer patients: different approaches, different visions
BackgroundBecause of their specific and biologically relevant cargo, urine extracellular vesicles (EVs) constitute a valuable source of potential...
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Cardiomyocyte microvesicles: proinflammatory mediators after myocardial ischemia?
Myocardial infarction is a frequent complication of cardiovascular disease leading to high morbidity and mortality worldwide. Elevated C-reactive...
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Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?
There are concepts in science that need time to overcome initial disbelief before finally arriving at the moment when they are embraced by the...
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Platelet microvesicles are associated with the severity of coronary artery disease: comparison between peripheral and coronary circulation
Microvesicles (MVs) have recently emerged as markers of thrombosis. Furthermore, there is an unexplained residual thrombotic risk is observed in...
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Impact of Diabetes Mellitus on the Potential of Autologous Stem Cells and Stem Cell–Derived Microvesicles to Repair the Ischemic Heart
Ischemic heart disease remains the leading cause of morbidity and mortality worldwide. Despite the advances in medical management and catheter-based...
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LY86, LRG1 and PDE9A genes overexpression in umbilical cord blood hematopoietic stem progenitor cells by acute myeloid leukemia (M3) microvesicles
BackgroundMicrovesicles as a new device of cell–cell communication are potentially able to induce some phenotypes and genotypes of an origin cell in...
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Tissue factor activity on microvesicles from cancer patients
PurposeThe expression of active tissue factor (TF) on the surface of microvesicles (MVs) is essential for the activation of the coagulation system...
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miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes
PurposeType 2 diabetes frequently remains undiagnosed for years, whereas early detection of affected individuals would facilitate the implementation...
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Extracellular vesicles: from bench to bedside
Extracellular vesicles (EVs) are cell-derived membrane-bound vesicles with heterogenous contents, including genetic materials, proteins, lipids and...
