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Genetic contribution to microglial activation in schizophrenia
Several lines of evidence indicate the involvement of neuroinflammatory processes in the pathophysiology of schizophrenia (SCZ). Microglia are brain...
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Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies
β-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer’s disease (AD), and biomarkers...
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Platelet-rich plasma alleviates neuropathic pain in osteoarthritis by downregulating microglial activation
BackgroundThe development of neuropathic pain (NP) is one of the reasons why the pain is difficult to treat, and microglial activation plays an...
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Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress
Running exercise has been shown to alleviate depressive symptoms. However, the mechanism underlying the antidepressant effects of running exercise is...
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Maternal Uterine Artery Adenoviral Vascular Endothelial Growth Factor (Ad.VEGF-A165) Gene Therapy Normalises Fetal Brain Growth and Microglial Activation in Nutrient Restricted Pregnant Guinea Pigs
Fetal growth restriction (FGR) is associated with uteroplacental insufficiency, and neurodevelopmental and structural brain deficits in the infant....
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Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells
ObjectiveThe activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral inflammation....
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Abnormal levels of expression of microRNAs in peripheral blood of patients with traumatic brain injury are induced by microglial activation and correlated with severity of injury
BackgroundMicroglia play a crucial role in regulating the progression of traumatic brain injury (TBI). In specific, microglia can self-activate and...
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AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization
BackgroundEnergy metabolism disorders and neurogenic inflammation play important roles in the central sensitization to chronic migraine (CM)....
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Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles
BackgroundIncreased maternal interleukin (IL)-17A and activated microglia are pivotal factors contributing to the pathological phenotypes of maternal...
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Sustained microglial activation in the area postrema of collagen-induced arthritis mice
BackgroundCentral nervous system (CNS)-mediated symptoms, such as fatigue, depression, and hyperalgesia, are common complications among patients with...
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Microglial Activation and Neurological Outcomes in a Murine Model of Cardiac Arrest
BackgroundNeurological injury following successful resuscitation from sudden cardiac arrest (CA) is common. The pathophysiological basis of this...
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The gut microbiome modulates the transformation of microglial subtypes
Clinical and animal studies have shown that gut microbiome disturbances can affect neural function and behaviors via the microbiota–gut–brain axis,...
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Microglial contribution to the pathology of neurodevelopmental disorders in humans
Microglia are the brain’s resident macrophages, which guide various developmental processes crucial for brain maturation, activity, and plasticity....
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Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors
BackgroundPerioperative neurocognitive disorders (PND) with a high incidence frequently occur in elderly surgical patients closely associated with...
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Microglial TLR4 is Critical for Neuronal Injury and Cognitive Dysfunction in Subarachnoid Hemorrhage
BackgroundToll-like receptor 4 (TLR4) activation causes excessive production of proinflammatory mediators and an increased expression of...
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TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids
Three Prime Repair Exonuclease 1 ( TREX1 ) gene mutations have been associated with Aicardi-Goutières Syndrome (AGS) – a rare, severe pediatric...
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Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation
BackgroundCentral sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal...
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Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion
Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder of genetic etiology, characterized by paternal deletion of genes located at...
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Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes...
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Repercussions of microglial efferocytosis on neurodegeneration in Alzheimer’s Disease (AD): a double-edged sword and perplexing factor warranting scrutiny in AD research
BackgroundAlzheimer’s disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) and tau aggregates within...
