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Anesthesia for deep brain stimulation system implantation: adapted protocol for awake and asleep surgery using microelectrode recordings
PurposeDeep brain stimulation (DBS), an effective treatment for movement disorders, usually involves lead implantation while the patient is awake and...
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Globus pallidus internus activity during simultaneous bilateral microelectrode recordings in status dystonicus
Limited data are available regarding the electrophysiology of status dystonicus (SD). We report simultaneous microelectrode recordings (MERs) from...
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Deep brain stimulation of the dentato-rubro-thalamic tract in a case of Holmes tremor: a constrained spherical deconvolution (CSD)–guided procedure
Deep brain stimulation (DBS) is an established treatment for movement disorders, including Holmes tremor (HT). HT is a rest and action tremor that...
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Somatosensory evoked potentials recorded from DBS electrodes: the origin of subcortical N18
The different peaks of somatosensory-evoked potentials (SEP) originate from a variety of anatomical sites in the central nervous system. The origin...
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Differential control of sympathetic outflow to muscle and skin during physical and cognitive stressors
PurposeSympathetic nerve activity towards muscle (MSNA) and skin (SSNA) regulates various physiological parameters. MSNA primarily functions in blood...
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The association between sleep duration and muscle sympathetic nerve activity
PurposeSleep duration is associated with risk of hypertension and cardiovascular diseases. It is thought that shorter sleep increases sympathetic...
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Technological advances in ventricular tachycardia catheter ablation: the relentless quest for novel solutions to old problems
BackgroundSeveral novel technologies allowing catheter ablation (CA) with a favorable safety/efficacy profile have been recently developed, but not...
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Factors influencing the reliability of intraoperative testing in deep brain stimulation for Parkinson’s disease
BackgroundSeveral meta-analyses comparing the outcome of awake versus asleep deep brain stimulation procedures could not reveal significant...
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Automatic identification of sweet spots from MERs for electrodes implantation in STN-DBS
PurposeMicroelectrode recordings (MERs) are a significant clinical indicator for sweet spots identification of implanted electrodes during deep brain...
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Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus
BackgroundMigraine is a disabling neurological disorder, characterized by recurrent headaches. During migraine attacks, individuals often experience...
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Recording and quantifying sympathetic outflow to muscle and skin in humans: methods, caveats and challenges
The development of microneurography, in which the electrical activity of axons can be recorded via an intrafascicular microelectrode inserted through...
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Targeting of the Subthalamic Nucleus in Patients with Parkinson’s Disease Undergoing Deep Brain Stimulation Surgery
Precise stereotactic targeting of the dorsolateral motor part of the subthalamic nucleus (STN) is paramount for maximizing clinical effectiveness and...
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Differential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function
Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such as bipolar disorder and...
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GFAP-NpHR mediated optogenetic inhibition of trigeminal nucleus caudalis attenuates hypersensitive behaviors and thalamic discharge attributed to infraorbital nerve constriction injury
The significance of hyperactive astrocytes in neuropathic pain is crucial. However, the association between medullary astrocytes and trigeminal...
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Continuous subcutaneous apomorphine infusion allowing awake deep brain stimulation in a Parkinson’s disease patient
BackgroundSubthalamic Deep Brain Stimulation (DBS) have demonstrated in the last decades to determine an important clinical improvement in advanced...
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Neuromotor prosthetic to treat stroke-related paresis: N-of-1 trial
BackgroundFunctional recovery of arm movement typically plateaus following a stroke, leaving chronic motor deficits. Brain-computer interfaces (BCI)...
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Prenatal LPS leads to increases in RAS expression within the PVN and overactivation of sympathetic outflow in offspring rats
The renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) are two major blood pressure-regulating systems. The link between the...
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Wireless facial biosensing system for monitoring facial palsy with flexible microneedle electrode arrays
Facial palsy (FP) profoundly influences interpersonal communication and emotional expression, necessitating precise diagnostic and monitoring tools...
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Epilepsy related to focal neuronal lipofuscinosis: extra-frontal localization, EEG signatures and GABA involvement
Focal neuronal lipofuscinosis (FNL) is an uncommon epileptic disorder related to an excess of lipofuscin accumulation within dysmorphic-appearing...
