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LSD increases sleep duration the night after microdosing
Microdosing psychedelic drugs at a level below the threshold to induce hallucinations is an increasingly common lifestyle practice. However, the...
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Experiences of microdosing psychedelics in an attempt to support wellbeing and mental health
BackgroundMicrodosing psychedelic drugs is a growing phenomenon, but little is known about the experiences surrounding this. Research broadly...
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An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)
BackgroundGlobally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative...
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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
The use of low sub-perceptual doses of psychedelics (“microdosing”) has gained popularity in recent years. Although anecdotal reports claim multiple...
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PAM trial protocol: a randomised feasibility study of psychedelic microdosing–assisted meaning-centred psychotherapy in advanced stage cancer patients
BackgroundAn advanced cancer diagnosis can be associated with a significant profile of distress. Psychedelic compounds have shown clinically...
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Factors that distinguish opioid withdrawal during induction with buprenorphine microdosing: a configurational analysis
BackgroundNovel buprenorphine dosing strategies have emerged with an aim to transition patients from opioid agonists to buprenorphine without...
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Feasibility of fluorescence imaging at microdosing using a hybrid PSMA tracer during robot-assisted radical prostatectomy in a large animal model
BackgroundWith the rise of prostate-specific membrane antigen (PSMA) radioguided surgery, which is performed using a microdosing regime, demand for...
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Microdosing as a Potential Tool to Enhance Clinical Development of Novel Antibiotics: A Tissue and Plasma PK Feasibility Study with Ciprofloxacin
Background and ObjectiveIn microdose studies, drug pharmacokinetics is measured in humans after administration of subtherapeutic doses. While...
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Case report: Successful induction of buprenorphine/naloxone using a microdosing schedule and assertive outreach
BackgroundThe requirement for moderate withdrawal prior to initiation can be a barrier to buprenorphine/naloxone induction.
Case presentation ...
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Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders....
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Twenty percent better with 20 micrograms? A qualitative study of psychedelic microdosing self-rapports and discussions on YouTube
BackgroundPsychedelic microdosing is the trending practice of using tiny repeated doses of psychedelic substances to facilitate a range of supposed...
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Psychedelic microdosing benefits and challenges: an empirical codebook
BackgroundMicrodosing psychedelics is the practice of consuming very low, sub-hallucinogenic doses of a psychedelic substance, such as lysergic acid...
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Using quality improvement approaches to increase emergency department provider engagement in research participant enrollment during COVID-19 and opioid overdose public health emergencies
PurposeWe utilized quality improvement (QI) approaches to increase emergency department (ED) provider engagement with research participant enrollment...
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Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice
Psilocybin and other serotonergic psychedelics have re-emerged as therapeutics for neuropsychiatric disorders, including addiction. Psilocybin...
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Cannabinoid extract in microdoses ameliorates mnemonic and nonmnemonic Alzheimer’s disease symptoms: a case report
BackgroundCannabinoid-based therapy has been shown to be promising and is emerging as crucial for the treatment of cognitive deficits, mental...
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MDLSD: study protocol for a randomised, double-masked, placebo-controlled trial of repeated microdoses of LSD in healthy volunteers
BackgroundRegular ingestion of sub-hallucinogenic doses of psychedelics, referred to as “microdosing”, has gained increasing popularity and attention...
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Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single,...
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Transition from Oxycodone to Buprenorphine/Naloxone in a Hospitalized Patient with Sickle Cell Disease: A Case Report
Buprenorphine is increasingly used to treat pain in patients with sickle cell disease but optimal timing and approach for transitioning patients from...
