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Mechanical overloading-induced miR-325-3p reduction promoted chondrocyte senescence and exacerbated facet joint degeneration
ObjectiveLumbar facet joint (LFJ) degeneration is one of the main causes of low back pain (LBP). Mechanical stress leads to the exacerbation of LFJ...
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MiR-325-3p Alleviates Acute Pancreatitis via Targeting RIPK3
Background and AimsAcute pancreatitis (AP) is an acute inflammatory disease that can lead to death. Mir-325-3p is strongly and abnormally expressed...
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Regulation of mRNA and miRNA in the response to Salmonella enterica serovar Enteritidis infection in chicken cecum
BackgroundSalmonella enterica , serovar Enteritidis (SE) is a food-borne pathogen, which can cause great threat to human health through consumption...
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Circulating miRNAs as potential biomarkers for light intensity exercise-induced enhancements in empathy
PurposeExercise positively impacts social abilities like empathy, which is indispensable for sustaining relationships with others. Regular exercise...
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BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway
ObjectivePeritoneal fibrosis (PF) is the main cause of declining efficiency and ultrafiltration failure of the peritoneum, which restricts the...
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Global research states and trends of micro RNA in irritable bowel syndrome: a bibliometric analysis
Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder, but its diagnosis and treatment remain obscure. Non-coding RNAs...
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Moderate evidence exists for four microRNAs as potential biomarkers for tendinopathies and degenerative tendon ruptures at the upper extremity in elderly patients: conclusion of a systematic review with best-evidence synthesis
PurposeThe aim of this systematic review was to investigate tendon-specific microRNAs (miRNAs) as biomarkers for the detection of tendinopathies or...
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Circulating miR-26b-5p and miR-451a as diagnostic biomarkers in medullary thyroid carcinoma patients
Purpose/methodsThe determination of tumour biomarkers is paramount to advancing personalized medicine, more so in rare tumours like medullary thyroid...
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Association of Blood MicroRNA Expression and Polymorphisms with Cognitive and Biomarker Changes in Older Adults
BackgroundIdentifying individuals before the onset of overt symptoms is key in the prevention of Alzheimer’s disease (AD).
Objkectives ...
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The role of exosomes in pathogenesis and the therapeutic efficacy of mesenchymal stem cell-derived exosomes against Parkinson’s disease
Parkinson’s disease (PD) is a chronic, progressive, neurodegenerative disease. The predominant pathology of PD is the loss of dopaminergic cells in...
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Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems
Diabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major...
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CircGFPT1 regulates the growth and apoptosis of esophageal squamous cell carcinoma through miR-142-5p/HAX1 axis
BackgroundCurrently, multiple circular RNAs (circRNAs) have been verified to act as essential regulators in the progression of esophageal squamous...
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Clinical applications of stem cell-derived exosomes
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it...
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New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics
Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of the gut–brain axis, intestinal permeability, mucosal...
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Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) is a common condition associated with critically ill patients, characterized by bilateral chest...
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Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity,...
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The critical role of circular RNAs in drug resistance in gastrointestinal cancers
Nowadays, drug resistance (DR) in gastrointestinal (GI) cancers, as the main reason for cancer-related mortality worldwide, has become a serious...
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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and...
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Increased expression of miR-224-5p in circulating extracellular vesicles of patients with reduced coronary flow reserve
BackgroundEndothelial and microvascular dysfunction are pivotal causes of major adverse cardiac events predicted by coronary flow reserve (CFR)....
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MicroRNA Signature and Cellular Characterization of Undifferentiated and Differentiated House Ear Institute-Organ of Corti 1 (HEI-OC1) Cells
MicroRNAs (miRNAs) regulate gene expressions and control a wide variety of cellular functions. House Ear Institute-Organ of Corti 1 (HEI-OC1) cells...
