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Matrix metalloproteinases in arthritis: towards precision medicine
Proteolysis of structural molecules of the extracellular matrix (ECM) is an irreversible post-translational modification in all arthropathies. Common...
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Matrix metalloproteinases in coronary artery disease and myocardial infarction
Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. Most cardiovascular deaths are caused by ischaemic heart diseases such as...
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Mendelian Randomization Study of the Relationship Between Serum Matrix Metalloproteinases and the Occurrence of Sepsis
BackgroundObservational studies have shown that matrix metalloproteinases (MMPs) are associated with sepsis. However, it is unknown whether this...
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Photobiomodulation effects in metalloproteinases expression in zymosan-induced arthritis
Matrix metalloproteinases (MMPs) play a crucial role in the degenerative course of rheumatic disorders. They are responsible for cartilage and other...
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Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium
BackgroundThe aetiology of delirium is not known, but pre-existing cognitive impairment is a predisposing factor. Here we explore the associations...
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The FoxP1 gene regulates lung function, production of matrix metalloproteinases and inflammatory mediators, and viability of lung epithelia
BackgroundGenes involved in lung development may become dysregulated in adult life and contribute to the pathogenesis of lung diseases. Multiple...
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Matrix Metalloproteinases (MMP-2) and Tissue Inhibitors of Metalloproteinases (TIMP-2) in Male Inguinal Hernia Patients at Different Ages
BackgroundCollagen metabolism, controlled by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), might be related...
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The effects of statin therapy on aneurysm size, growth rate, and matrix metalloproteinases-9 levels in patients with aortic aneurysm: a systematic review and meta-analysis
BackgroundAortic aneurysm enlargement over time causes rupture, which frequently results in death. The family of proteases known as matrix...
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Understanding the Role of Metalloproteinases and Their Inhibitors in Periodontology
Periodontitis is a complex and inflammatory disorder characterized by elevated level of tissue-degrading enzymes leading to the destruction of...
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Time trajectories and within-subject correlations of matrix metalloproteinases 3, 8, 9, 10, 12, and 13 serum levels and their ability to predict mortality in polytraumatized patients: a pilot study
BackgroundManaging polytrauma victims poses a significant challenge to clinicians since applying the same therapy to patients with similar injury...
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The role of matrix metalloproteinases in patients with pulmonary hypertension: data from a prospective study
BackgroundDespite several therapies, pulmonary hypertension (PH) is still a severe disease which can lead to right heart failure. Matrix...
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Expression deregulation of matrix metalloproteinases and vasoconstriction related genes in Pakistani females with abnormal uterine bleeding
BackgroundAbnormal uterine bleeding (AUB) is irregular menstrual bleeding which has great impact on female health and life style. Various genetic...
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CELF1 promotes matrix metalloproteinases gene expression at transcriptional level in lens epithelial cells
BackgroundRNA binding proteins (RBPs)-mediated regulation plays important roles in many eye diseases, including the canonical RBP CELF1 in cataract....
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Regulation of interleukin-6 and matrix metalloproteinases syntheses by bioflavonoids and photobiomodulation in human gingival fibroblasts
This study aimed to evaluate the separately effects of bioflavonoids proanthocyanidins, from grape seed extract (GSE) and synthetic naringenin (NA),...
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Prognosticating acute traumatic spinal cord injury using Neurofilament (NF), Neuron Specific Enolase (NSE), Matrix Metalloproteinases (MMPs), and S-100B as biomarkers
BackgroundSpinal cord injury (SCI) can result in lifelong disability. Currently, the literature suggests that biomarkers are helpful in...
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Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes
PurposeMatrix metalloproteinases (MMPs) are identified as modulators of the extracellular matrix in heart failure progression. However, evidence for...
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Matrix Metalloproteinases (MMP-2) and Tissue Inhibitors of Metalloproteinases (TIMP-2) in Patients with Inguinal Hernias
BackgroundThe development of inguinal hernia might be related with collagen metabolism, which was regulated by matrix metalloproteinases (MMPs) and...
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Expression pattern of matrix metalloproteinases-2 and -9 and their tissue inhibitors in patients with chronic inflammatory demyelinating polyneuropathy
BackgroundMatrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play a role in many physiological functions, including...
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Value of metalloproteinases in predicting COPD in heavy urban smokers
BackgroundEmphysema in asymptomatic heavy smokers can be detected during CT-scan screening for lung cancer. Metalloproteinases (MMPs) have been found...
