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Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis
PurposeImmune checkpoint inhibitors (ICI) are effective against various malignancies. However, adverse events including diarrhea and colitis can lead...
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Peri-myocarditis caused by topical rectal mesalamine
Peri-myocarditis has been associated to mesalamine use. The definite association and use of topical rectal mesalamine to peri-myocarditis is not...
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Recent advances in mesalamine colonic delivery systems
BackgroundIncreased attention has been focused on the continuous development and improvement of mesalamine colonic specific delivery systems, for the...
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Chronic radiation proctitis refractory to steroid enema was successfully treated by metformin and sodium butyrate: a case report
BackgroundRadiation proctitis (RP) is a significant complication of pelvic radiation. Effective treatments for chronic RP are currently lacking. We...
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Real-world NUDT15 genoty** and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study
BackgroundThis study evaluated the effectiveness of NUDT15 codon 139 genoty** in optimizing thiopurine treatment for inflammatory bowel disease...
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The culprit of mesalamine intolerance: case series and literature review
BackgroundMesalamine is a first-line drug in the treatment of inflammatory bowel diseases, while its intolerance occasionally occurs in clinical...
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Hyposensitization trial using salazosulfapyridine in a case of mesalamine intolerance
A 47-year-old Japanese man was diagnosed with pancolitis-type ulcerative colitis. He was treated with mesalamine in a pH-dependent release form. On...
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Real world evidence of the association between medication and life expectancy in elderly inflammatory bowel disease: a population-based cohort study
BackgroundLife expectancy in people with inflammatory bowel disease (IBD) has increased but remains shorter than in people without IBD. We describe...
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Identifying Measures of Suboptimal Healthcare Interaction (SOHI) to Develop a Claims-Based Model for Predicting Patients with Inflammatory Bowel Disease at Risk for SOHI
BackgroundUnderstanding the demographic and clinical characteristics of patients with Inflammatory Bowel Disease (IBD) who are likely to experience...
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Design expert as a statistical tool for optimization of 5-ASA-loaded biopolymer-based nanoparticles using Box Behnken factorial design
BackgroundThe overall objective was to prepare a highly accurate nanocarrier system of mesalamine for the treatment of ulcerative colitis with...
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The long-term effect on surgery-free survival of biological compared to conventional therapy in Crohn’s disease in real world-data: a retrospective study
BackgroundThe introduction of biological drugs has led to great expectations and growing optimism in the possibility that this new therapeutic...
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Current Guidelines and Controversies in the Management of Diverticulitis
Purpose of ReviewThis review discusses the most recent studies and guidelines regarding the treatment of acute diverticulitis. It specifically...
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The Sasaki-W anastomosis for recurrent Crohn’s disease stenosis after the Kono-S anastomosis
BackgroundPostoperative recurrence is frequently encountered in the management of patients with Crohn’s disease and is most often found at the...
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Anti-TNF Agents and New Biological Agents (Vedolizumab and Ustekinumab) in the Prevention and Treatment of Postoperative Recurrence After Surgery in Crohn’s Disease
Surgery for Crohn’s disease (CD) is not curative, as postoperative recurrence (POR) after ileocolonic resection is the rule in the absence of...