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New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System
γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the mammalian brain and has been found to play an important role in...
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Lorcaserin for Dravet Syndrome: A Potential Advance Over Fenfluramine?
Lorcaserin, a selective serotonin 5-HT 2C receptor agonist, was developed as an appetite suppressant with the rationale of minimizing the risk of...
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Effects of berberine on pentylenetetrazole-induced seizures during estrus cycle in rats
Catamenial epilepsy is one of the central brain-related disorders associated with a menstrual cycle in some epileptic women. This study aimed to...
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A review on epilepsy, current treatments, and potential of medicinal plants as an alternative treatment
Epilepsy is considered common neurological diseases that threaten the lives of millions of people all around the world. Since ancient times,...
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The role of angiotensin receptor blockers in treating epilepsy: a review
Epilepsy is a chronic brain disease with a global prevalence of 70 million people. According to the World Health Organization, roughly 5 million new...
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Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties
BackgroundEpilepsy is a chronic neurological condition that disrupts the normal functioning of the brain and it is characterized by seizures....
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New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the modulation of neuronal excitability, and a disruption of...
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Comparison of intranasal and intraperitoneal administration of Eugenia caryophyllata (clove) essential oil on spatial memory, anxiety-like behavior and locomotor activity in a pilocarpine-induced status epilepticus rat model
BackgroundEpilepsy induces behavioral effects and histological changes in the hippocampus. Eugenol, the main component of clove essential oil, has...
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HMGB1, neuronal excitability and epilepsy
Epilepsy is a common neurological disease caused by synchronous firing of hyperexcitable neurons. Currently, anti-epileptic drugs remain the main...
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Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome
ObjectiveCannabigerolic acid (CBGA), a precursor cannabinoid in Cannabis sativa , has recently been found to have anticonvulsant properties in the Scn1a...
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The effect of gabapentin and pregabalin administration on memory in clinical and preclinical studies: a meta-analysis and systematic review
BackgroundToday , gabapentinoids such as Gabapentin (GBP) and pregabalin (PGB) are widely used as painkillers. This may alter the function of the...
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Narrative Review of Brivaracetam: Preclinical Profile and Clinical Benefits in the Treatment of Patients with Epilepsy
One third of patients with epilepsy will continue to have uncontrolled seizures despite treatment with antiseizure medications (ASMs). There is...
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Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug–Drug Interactions and Tolerability
Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended...
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AMPK role in epilepsy: a promising therapeutic target?
Epilepsy is a complex and multifaceted neurological disorder characterized by spontaneous and recurring seizures. It poses significant therapeutic...
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Pharmacological perspectives and mechanisms involved in epileptogenesis
BackgroundEpileptogenesis can be defined as the process by which a previously healthy brain develops a tendency toward recurrent electrical activity,...
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Triazole analogues as potential pharmacological agents: a brief review
BackgroundA large number of studies have recently reported that, because of their significant biological and pharmacological properties, heterocyclic...
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Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic–clonic seizure model in mice
Increasing evidence indicates that some antiarrhythmic drugs play a pivotal role in seizures, not only in vivo studies on animals, but also in...
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Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry
Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people worldwide. Patients with status epilepticus (SE) suffer...
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The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond
Epilepsy is one of the most common and disabling chronic neurological disorders. Antiseizure medications (ASMs), previously referred to as...
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Therapeutic benefits of gossypin as an emerging phytoconstituents of Hibiscus spp.: a critical review
BackgroundFlavonoids are one of the crucial secondary metabolites as several functions are carried out by flavonoids, including regulating cell...
