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HOMA-IR and the Matsuda Index as predictors of progression to type 1 diabetes in autoantibody-positive relatives
Aim/hypothesisWe assessed whether HOMA-IR and the Matsuda Index are associated with transitions through stages of type 1 diabetes.
Methods ...
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Contribution of Insulin Resistance and β Cell Dysfunction to Gestational Diabetes Stratified for Pre-pregnant Body Mass Index
The objective of the study was to evaluate the contribution of insulin resistance and β cell dysfunction to gestational diabetes mellitus (GDM) in...
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Associations of four surrogate insulin resistance indexes with non-alcoholic steatohepatitis in Chinese patients with obesity: a cross-sectional study
ObjectivesThis study was designed to evaluate the association of four surrogate indexes of IR with NASH in patients with obesity.
Methods ...
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The relationships between FLAIS, a novel insulin sensitivity index, and cardiovascular risk factors in a population-based study
BackgroundInsulin resistance is a risk factor for cardiovascular disease. Recently, we have developed a novel index, FLAIS (Fasting Laboratory...
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Modifiable predictors of type 2 diabetes mellitus and roles of insulin resistance and β-cell function over a 6-year study and 30-year follow-up
PurposeThis study aimed to examine the modifiable predictors of T2DM and the roles of insulin resistance (IR) and β-cell function over a 6-year study...
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Deteriorating beta cell function is the dominant determinant of progression from normal glucose tolerance to prediabetes/diabetes in young women following pregnancy
Aims/hypothesisExcess adiposity, insulin resistance and beta cell dysfunction each contribute to the development of prediabetes (impaired glucose...
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Adipose tissue insulin resistance predicts the incidence of hypertension: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases
We investigated the association of adipose tissue insulin resistance with blood pressure and hypertension incidence, comparing it with hepatic and...
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Exploring the association between triglyceride-glucose index and thyroid function
BackgroundThyroid dysfunction is associated with abnormal glucose-insulin homeostasis, and the triglyceride-glucose (TyG) index has been recommended...
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Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case–control study
BackgroundInsulin resistance affects a substantial proportion of patients with rheumatoid arthritis (RA). Skeletal muscle mitochondrial dysfunction...
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Postpartum weight retention and the early evolution of cardiovascular risk over the first 5 years after pregnancy
BackgroundThe cumulative effect of postpartum weight retention from each pregnancy in a woman’s life may contribute to her risk of ultimately...
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Central and peripheral sensitivity to thyroid hormones and glucose metabolism in prepubertal children with obesity: pilot multicenter evaluation
PurposeAn alteration of central and peripheral sensitivity to thyroid hormones (THs) seems to be associated with an increased risk of prediabetes in...
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Glucose dysregulation and subclinical cardiac dysfunction in older adults: The Cardiovascular Health Study
ObjectiveWe evaluated whether measures of glucose dysregulation are associated with subclinical cardiac dysfunction, as assessed by speckle-tracking...
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Hepatic fibrosis: a manifestation of the liver disease evolution in patients with Ataxia-telangiectasia
BackgroundAtaxia-telangiectasia (A-T) is a DNA repair disorder characterized by changes in several organs and systems. Advances in clinical protocols...
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Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo—The Maastricht Study
ObjectiveWe investigated, using population-based data, whether worse autonomic function, estimated from lower 24-hour heart rate variability (HRV),...
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Τriglycerides-glucose (TyG) index is a sensitive marker of insulin resistance in Greek children and adolescents
PurposeTo investigate the association between Triglyceride-glucose (TyG) index and the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)...
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C-reactive protein during pregnancy and in the early postpartum predicts adverse metabolic health outcomes at 1 year postpartum in women with gestational diabetes
BackgroundWomen with gestational diabetes mellitus (GDM) have higher insulin resistance and/or reduced secretion, an increased risk of future...
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Association between serum 25-hydroxyvitamin-D and Triglycerides-Glucose index among Indian adolescents
BackgroundVitamin D deficiency has been found to associated with numerous skeletal and non-skeletal diseases including Diabetes Mellitus. Insulin...
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The colon inflammatory index score can predict the survival outcome after resection of colorectal cancer: a retrospective multicentre study
PurposeMany systemic inflammatory markers have been identified to be prognostic factors in various diseases, including colorectal cancer (CRC). The...
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FADS cluster variants are associated with insulin sensitivity in children and adolescents with overweight and obesity
Changes in the desaturation activity of LC-PUFAs may influence insulin sensitivity by modulating the relative abundance of omega-3. The aim of this...
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MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial
Aims/hypothesisA type 2 diabetes-risk-increasing variant, MTNR1B (melatonin receptor 1B) rs10830963, regulates the circadian function and may...
