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A case of crystalglobulin-induced nephropathy wherein M protein was identified by mass spectrometry and immunoglobulin G subclass staining
Crystalglobulin-induced nephropathy is a rare disease that causes the deposition of crystallized monoclonal immunoglobulins into the glomerular...
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Mass spectrometry detection of inhaled drug in distal fibrotic lung
BackgroundCurrently the only available therapies for fibrotic Interstitial Lung Disease are administered systemically, often causing significant side...
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Practical application guide for the discovery of novel PFAS in environmental samples using high resolution mass spectrometry
BackgroundThe intersection of the topics of high-resolution mass spectrometry (HRMS) and per- and polyfluoroalkyl substances (PFAS) bring together...
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The application of mass spectrometry imaging in traditional Chinese medicine: a review
Mass spectrometry imaging is a frontier technique which connects classical mass spectrometry with ion imaging. Various types of chemicals could be...
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Detection of IEMs by Mass Spectrometry Techniques in High-Risk Children: A Pilot Study
ObjectivesTo determine the incidence and types of inborn errors of metabolism (IEMs) in high-risk children using mass spectrometry techniques.
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Short-term culture for rapid identification by mass spectrometry and automated antimicrobial susceptibility testing from positive bottles
BackgroundEarly and appropriate antibiotic treatment improves the clinical outcome of patients with sepsis. There is an urgent need for rapid...
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Liquid chromatography-mass spectrometry-based metabolomic profiling reveals sex differences of lipid metabolism among the elderly from Southwest China
BackgroundThe sexual dimorphism represents one of the triggers of the metabolic disparities while the identification of sex-specific metabolites in...
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A case of juvenile-onset fibrillary glomerulonephritis diagnosed by mass spectrometry and immunohistochemistry of DNAJB9
Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. FGN is characterized by the deposition of randomly arranged, nonbranching...
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Circulating level of β-aminoisobutyric acid (BAIBA), a novel myokine-like molecule, is inversely associated with fat mass in patients with heart failure
Results of experimental studies have shown that β-aminoisobutyric acid (BAIBA), an exercise-induced myokine-like molecule, is an endogenous negative...
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A novel strategy for screening mutations in the voltage-gated sodium channel gene of Aedes albopictus based on multiplex PCR-mass spectrometry minisequencing technology
BackgroundThe current prevention and control strategy for Aedes albopictus heavily relies on comprehensive management, such as environmental...
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Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation
BackgroundTo adapt to life on land, Asiatic toads ( Bufo gargarizans ) must remodel their bodies and refine their chemical defenses in water. The full...
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First liquid chromatography–high resolution mass spectrometry method for the determination of cocaine on banknote dust
PurposePrevalence measures of sociological interest concerning cocaine presence on banknotes are fraught with (i) the extreme variability of its...
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Urinary metabolomics using gas chromatography-mass spectrometry: potential biomarkers for autism spectrum disorder
BackgroundDiagnosis of autism spectrum disorder (ASD) is generally made phenotypically and the hunt for ASD-biomarkers continues. The purpose of this...
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Early onset and liver failure indicating poor prognosis of infant liver failure syndrome type 1
BackgroundInfantile liver failure syndrome type 1 (ILFS1, OMIM #615,438), caused by leucyl-tRNA synthase 1 ( LARS1 , OMIM *151,350) deficiency, is a...
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Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry
Prostate cancer is the second most frequently diagnosed non-skin cancer in men worldwide. Patient outcomes are remarkably heterogeneous and the best...
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Characterization of Plasma SDS-Protein Aggregation Profile of Patients with Heart Failure with Preserved Ejection Fraction
This study characterizes the plasma levels and composition of SDS-resistant aggregates (SRAs) in patients with heart failure with preserved ejection...
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Pediatric acute liver failure: Current perspective in etiology and management
Pediatric acute liver failure (PALF) is a catastrophic clinical condition with very high morbidity and mortality without early detection and...
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The analysis of ramipril/ramiprilat concentration in human serum with liquid chromatography-tandem mass spectrometry – interpretation of high concentrations for the purposes of forensic toxicology
Ramipril is a popular angiotensin-converting enzyme inhibitor applied in the treatment of hypertension. Its therapeutic effect is oriented on the...
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Pharmacokinetic profile of acyclovir in a child receiving continuous kidney replacement therapy for acute liver failure
BackgroundContinuous venovenous hemodiafiltration (CVVHDF) is one of the treatments of critically ill children presenting severe acute liver failure....
